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品种反应性 主要应用 宿主 格式 抗体类型 R, H ICC, WB Gt Purified Polyclonal Antibody 描述 产品目录编号 06-411 品牌系列 Upstate
商名 - Upstate
描述 Anti-PKA Antibody, RII Subunits 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide 应用 应用 Anti-PKA Antibody, RII Subunits is an antibody against PKA for use in IP, WB & IC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 Recombinant RII subunits of mouse cAMP-dependent protein kinase expressed in E. coli 宿主 Goat 特异性 RIIα and β subunits 同种型 IgG 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004157, NM_002736
Entrez基因汇总 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). 基因符号 - PRKAR2
- PRKAR2A
- MGC3606
- PKR2
纯化方法 Protein G chromatography UniProt编号 - P13861
UniProt汇总 FUNCTION: SwissProt: P13861 # Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
SIZE: 404 amino acids; 45518 Da
SUBUNIT: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3.
TISSUE SPECIFICITY: Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
PTM: Phosphorylated by the activated catalytic chain.
SIMILARITY: SwissProt: P13861 ## Belongs to the cAMP-dependent kinase regulatory chain family. & Contains 2 cyclic nucleotide-binding domains.产品使用声明 质量保证 routinely evaluated by immunoblot on mouse 3T3/A31 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 500 µg
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下一件merck millipore产品：merck millipore,默克密理博,AB2266,Anti-VPAC2 Antibody
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