merck millipore,默克密理愽
  • merck millipore,默克密理博,400088,HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem

  • merck millipore,默克密理博,400088,HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem

    产品名称：HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem
    产品型号：400088
    The HIF-1α Translation Inhibitor, KC7F2, also referenced under CAS 927822-86-4, controls the biological activity of HIF-1α. This small molecule/inhibitor is primarily used for Cell Structure applicati More>>

    merck millipore,默克密理博,400088,HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,400088,HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₆Cl₄N₂O₄S₄927822-86-4
    描述
    概述 A cell-permeable symmetrical cystamine compound that selectively suppresses cellular HIF-1α, but not HIF-1β, protein synthesis without affecting the transcription of HIF-1α mRNA or the stability of HIF-1α protein. Reduction of cellular HIF-1α by KC7F2 treatment (IC50 <20 µM in LN229 cultures under hypoxia condition) is shown to result in decreased transcriptions of HIF-1α-dependent genes, such as CA IX, endothelin 1, enolase 1, and MMP-2. Inhibition of 4EBP1 and S6K phosphorylation, important event for the initiation of protein translation, is also observed in KC7F2 and U87MGD cultures following KC7F2 treatment under hypoxia condition, which may account for, at least in part, the downregulated HIF-1α synthesis.
    产品目录编号 400088
    品牌系列 Calbiochem®
    同义词 Hypoxia-Inducible Factor-1α Translation Inhibitor, KC7F2, N,Nʹ-(2,5-Dichlorosulfonyl)cystamine, HIF Inhibitor III
    参考
    参考 Narita, T., et al. 2009. Clin. Cancer Res. 15, 6128.
    产品信息
    CAS号 927822-86-4
    形式 Beige to tan solid
    Hill配方 C₁₆H₁₆Cl₄N₂O₄S₄
    化学配方 C₁₆H₁₆Cl₄N₂O₄S₄
    Molar Mass 570.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,400088,HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem

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