merck millipore,默克密理愽
  • merck millipore,默克密理博,07-2242,Anti-phospho-c-Met (Tyr1230/1234/1235) Antibody

  • merck millipore,默克密理博,07-2242,Anti-phospho-c-Met (Tyr1230/1234/1235) Antibody

    产品名称：Anti-phospho-c-Met (Tyr1230/1234/1235) Antibody
    产品型号：07-2242
    This phospho-c-Met antibody is validated for use in WB & ICC for the detection of the phospho-c-Met protein.

    merck millipore,默克密理博,07-2242,Anti-phospho-c-Met (Tyr1230/1234/1235) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-2242,Anti-phospho-c-Met (Tyr1230/1234/1235) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Fe, H, M, R, Ca, ChpICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2242
    描述 Anti-phospho-c-Met (Tyr1230/1234/1235) Antibody
    Alternate Names
    • Tyrosine-protein kinase Met
    • Hepatocyte growth factor receptor
    • HGF receptor
    • HGF/SF receptor
    • Proto-oncogene c-Met
    • Scatter factor receptor
    • SF receptor
    背景信息 The c-MET protein (c-MET) is also sometimes referred to as the hepatocyte growth factor (HGF) receptor and is thought to be involved in angiogenesis, cellular motility, growth, invasion and differentiation. c-MET is a heterodimer made up of a 50 kda (alpha) disulfide linked chain and a 145 kda (beta) disulfide linked chain. c-MET has been shown to be greatly amplified in the gastric carcinoma cell line and this amplification has been linked to an advanced tumor stage and a poorer prognosis. c-MET has been shown to decrease the viability and growth of small cell lung cancer cell lines specifically and may be an interesting target for potential therapies for cancer in general.
    产品信息
    格式 Affinity Purified
    控制
    • HGF treated and untreated HeLa cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This phospho-c-Met antibody is validated for use in WB & ICC for the detection of the phospho-c-Met protein.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected c-Met in NIH/3T3 and HeLa cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human c-Met phosphorylated at Tyr1230, Tyr1234, and Tyr1235.
    表位 Phosphorylated Tyr1230, Tyr1234, Tyr1235
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes c-Met when phosphorylated at Tyr1230, Tyr1234, and Tyr1235.
    品种反应性 FelineHumanMouseRatCanineChimpanzee
    Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse, rat, canine, chimpanzee, and feline based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000236
    Entrez基因汇总 The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
    基因符号
    • MET
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • P08581
    UniProt汇总 FUNCTION: Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.

    CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    SUBUNIT STRUCTURE: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    DOMAIN: The kinase domain is involved in SPSB1 binding.

    INVOLVEMENT IN DISEASE: Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.

    Note=Defects in MET may be associated with gastric cancer.

    Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].

    Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.

    Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific transcription factor complexes.

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family.

    Contains 3 IPT/TIG domains.

    Contains 1 protein kinase domain.

    Contains 1 Sema domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HGF treated and untreated HeLa cell lysates.

    Western Blot Analysis: 1 µg/mL of this antibody detected c-Met on 10 µg of HGF treated and untreated HeLa cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-2242,Anti-phospho-c-Met (Tyr1230/1234/1235) Antibody

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