merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1516,Anti-hnRNP U Antibody, clone 3G6

  • merck millipore,默克密理博,05-1516,Anti-hnRNP U Antibody, clone 3G6

    产品名称：Anti-hnRNP U Antibody, clone 3G6
    产品型号：05-1516
    Use Anti-hnRNP U Antibody, clone 3G6 (mouse monoclonal antibody) validated in WB, IP, ICC, ELISA to detect hnRNP U also known as heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A More>>

    merck millipore,默克密理博,05-1516,Anti-hnRNP U Antibody, clone 3G6

  • 产品介绍
  • merck millipore,默克密理博,05-1516,Anti-hnRNP U Antibody, clone 3G6

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISA, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1516
    描述 Anti-hnRNP U Antibody, clone 3G6
    Alternate Names
    • p120 nuclear protein
    • Scaffold attachment factor A
    • heterogeneous nuclear ribonucleoprotein U
    • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
    • hnRNP U
    • hnRNP U protein
    背景信息 Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre-mRNA processing. However, its role in the regulation of gene expression is as yet poorly understood. Proteins of the heterogeneous nuclear ribonucleoparticles (hnRNP) family form a structurally diverse group of RNA binding proteins implicated in various functions. Recently, hnRNP proteins have been shown to hinder communication between factors bound to different splice sites. Conversely, several reports have described a positive role for some hnRNP proteins in pre-mRNA splicing. hnRNP-U, also termed scaffold attachment factor A (SAF-A), binds to pre-mRNA and nuclear matrix/scaffold attachment region DNA elements.
    产品信息
    格式 Purified
    控制
    • K562 cell lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Use Anti-hnRNP U Antibody, clone 3G6 (mouse monoclonal antibody) validated in WB, IP, ICC, ELISA to detect hnRNP U also known as heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A).
    主要应用
    • ELISA
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunoprecipitation
    Reported by external laboratory using a represenative lot of this antibody
    Immunocytochemistry
    Reported by external laboratory using a represenative lot of this antibody
    ELISA
    Reported by external laboratory using a represenative lot of this antibody
    生物信息
    免疫原品种 Recombinant protein corresponding to human hnRNP U.
    表位 Unknown
    克隆 3G6
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes hnRNP U.
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_004492.2
    Entrez基因汇总 This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq].
    基因符号
    • pp120
    • hnrnpu
    • HNRPU
    • SAF-A
    • SAFA
    • U21.1
    • hnRNPU
    • p120
    纯化方法 Protein G purfied
    UniProt编号
    • Q00839
    UniProt汇总 FUNCTION: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Bind to double- and single-stranded DNA and RNA.

    SUBUNIT STRUCTURE: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. Ligand for CR2.

    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell surface. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Also found associated with the cell surface.

    PTM: Extensively phosphorylated.

    Arg-733 and Arg-739 are dimethylated, probably to asymmetric dimethylarginine.

    SEQUENCE SIMILARITIES: Contains 1 B30.2/SPRY domain.

    Contains 1 SAP domain.

    SEQUENCE CAUTION: The sequence AAC19382.1 differs from that shown. Reason: Miscellaneous discrepancy. Aberrant splicing.
    产品使用声明
    质量保证 Evaluated by Western Blot in K562 cell lysate.

    Western Blot Analysis: 0.01 µg/ml of this antibody detected hnRNP U on 10 µg of K562 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1516,Anti-hnRNP U Antibody, clone 3G6

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