merck millipore,默克密理博,MABE176,Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone AB3/63.3

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
A	ICC	R	Purified	Monoclonal Antibody

描述
产品目录编号	MABE176
描述	Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone AB3/63.3
Alternate Names	5-hmC 5hmeC 5' hydroxymethyl cytosine 5'OH methyl cytosine 5'OHmeC 5hmc
背景信息	5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base formed from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of iron-dependent oxygenases. Data suggests that every mammilian cell contains 5-hydroxymethylcytosine, but the levels vary depending on the cell type; data also suggests that levels of 5-hydroxymethylcytosine increases with age. The highest levels are found in neuronal cells of the central nervous system and certain mammalian tissues such as mouse Purkinje and granule neurons. Although the exact function has not been fully elucidated, studies suggest that 5-hydroxymethlcytosine may regulate gene expression or initiate DNA demethylation.

产品信息
格式	Purified
控制	Unmodified DNA, 5-Methylcytosine DNA, and 5-hydroxymethylcytosine DNA
演示	Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone AB3/63.3 is a Rat monoclonal antibody for detection of 5-hydroxymethylcytosine also known as 5hmeC, 5' hydroxymethyl cytosine, 5'OH methyl cytosine, 5'OHmeC & has been validated in DB, ICC.
主要应用	Immunocytochemistry

生物信息
免疫原品种	5-Hydroxymethylcytosine conjugated to BSA
克隆	AB3/63.3
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rat
特异性	This antibody detects 5-hydroxymethyl cytosine, but not 5-methylcytosine or unmethylated cytosine.
同种型	IgG2aκ
品种反应性	All
Species Reactivity Note	Non-species specific antibody against modified DNA. Expected to detect 5-hydroxymethylcytosine in all species.
抗体类型	Monoclonal Antibody
纯化方法	Protein G purified

产品使用声明
质量保证	Evaluated by Dot Blot in a panel of unmodified DNA, 5-Methylcytosine DNA, and 5-hydroxymethylcytosine DNA. Dot Blot Analysis: 10 µg/mL and 1 µg/mL of this antibody detected 5-hydroxymethylcytosine in a panel of unmodified DNA, 5-Methylcytosine DNA, and 5-hydroxymethylcytosine DNA.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABE176,Anti-5-hydroxymethylcytosine (5hmC) Antibody, clone AB3/63.3

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