merck millipore,默克密理博,07-1841,Anti-acetyl-Tip60 Antibody (Lys523)

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merck millipore,默克密理博,07-1841,Anti-acetyl-Tip60 Antibody (Lys523)
产品名称：Anti-acetyl-Tip60 Antibody (Lys523)
产品型号：07-1841
Anti-acetyl-Tip60 (Lys523) is an antibody targeting the acetyl-Tip60 (Lys523) protein, validated for use in WB.

merck millipore,默克密理博,07-1841,Anti-acetyl-Tip60 Antibody (Lys523)

产品介绍

merck millipore,默克密理博,07-1841,Anti-acetyl-Tip60 Antibody (Lys523)

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Porcine	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-1841
描述	Anti-acetyl-Tip60 Antibody (Lys523)
Alternate Names	KAT5 Histone acetyltransferase KAT5 60 kDa Tat-interactive protein Tip60 Histone acetyltransferase HTATIP HIV-1 Tat interactive protein Lysine acetyltransferase 5 cPLA(2)-interacting protein
背景信息	Histone acetyltransferase HTATIP (Tip60) is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Direct binding of HTATIP to the TAT protein of the human immunodeficiency virus (HIV) might be an important feature for efficient TAT transactivation of HIV gene expression.

产品信息
格式	Affinity Purified
控制	Untreated and sodium butyate treated HeLa cell lysates.
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-acetyl-Tip60 (Lys523) is an antibody targeting the acetyl-Tip60 (Lys523) protein, validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to the C-terminus of human Tip60 acetylated at Lys523.
表位	C-terminus
宿主	Rabbit
特异性	This antibody recognizes the C-terminus of Tip60 acetylated at Lys523. This antibody is expect to react with all four known isoforms.
品种反应性	Porcine
Species Reactivity Note	Demonstrated to react with Human. Predicted to react with Mouse, Bovine, and Porcine based on 100% sequence homology. Other homologies: Xenopus (83% sequence homology).
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_874369
基因符号	TIP60 KAT5 HTATIP
纯化方法	Affinity purified
UniProt编号	Q92993-3

产品使用声明
质量保证	Evaluated by Western Blotting untreated and sodium butyrate treated HeLa cell lysates. Western Blotting Analysis: A 1:500 dilution from a representative lot detected Tip60 acetylated at Lys523 in 10 μg of untreated and Sodium Butyrate treated HeLa cell lysates, where primary antibody was preincubated without or with non-phosphorylated Tip60 peptide. A loss of signal was detected where primary antibody was preincubated with phosphorylated Tip60 peptide.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品使用声明

质量保证

Evaluated by Western Blotting untreated and sodium butyrate treated HeLa cell lysates.

Western Blotting Analysis: A 1:500 dilution from a representative lot detected Tip60 acetylated at Lys523 in 10 μg of untreated and Sodium Butyrate treated HeLa cell lysates, where primary antibody was preincubated without or with non-phosphorylated Tip60 peptide. A loss of signal was detected where primary antibody was preincubated with phosphorylated Tip60 peptide.

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.