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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1511 描述 Anti-phospho-WAVE2 (Ser308) Antibody Alternate Names - Verprolin homology domain-containing protein 2
- Wiskott-Aldrich syndrome protein family member 2
- WASP family protein member 2
- Protein WAVE-2
背景信息 Wiskott-Aldrich Syndrome Protein (WASP)-family Protein Member 2 (known as WAVE2) has a very wide distribution with strong expression in peripheral blood leukocytes. WAVE2 is involved in signaling RTKs and small GTPases. In general WAVE family of proteins have a general function for regulating the actin cytoskeleton in various tissues. 产品信息 格式 Affinity Purified 控制 - EGF-treated and untreated A431 cell lysates
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect phospho-WAVE2 (Ser308) using this Anti-phospho-WAVE2 (Ser308) Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: A previous lot of this antibody was used to detect phospho-WAVE2 (Ser308) in FLAG-WAVE2 transfected 293T cells (Mendoza, et al. (2011). Molecular Cell. 41:661-671). 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human WAVE2 phosphorylated at Ser308. 表位 Phosphorylated Ser308 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes WAVE2 phosphorylated at Ser308. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human.
Other homologies: Mouse and Rat (90% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_008921
Entrez基因汇总 Summary: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. 基因符号 - WASF2
- WAVE2
修改 - Phosphorylation
纯化方法 Affinity Purified UniProt编号 - Q9Y6W5
UniProt汇总 FUNCTION: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.
SUBUNIT STRUCTURE: Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300.
SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton (by similarity). Cell projection › lamellipodium (by similarity). Note: At the interface between the lamellipodial actin meshwork and the membrane (by similarity).
TISSUE SPECIFICITY: Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.
DOMAIN: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
SEQUENCE SIMILARITIES: Belongs to the SCAR/WAVE family. Contains 1 WH2 domain.产品使用声明 质量保证 Evaluated by Western Blot in EGF-treated and untreated A431 cell lysates.
Western Blot Analysis: 2 µg/mL of this antibody detected phospho-WAVE2 (Ser308) in 10 µg of EGF-treated and untreated A431 cell lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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