merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1079,Anti-Interleukin 23 alpha (IL-23A) Antibody

  • merck millipore,默克密理博,06-1079,Anti-Interleukin 23 alpha (IL-23A) Antibody

    产品名称：Anti-Interleukin 23 alpha (IL-23A) Antibody
    产品型号：06-1079
    Detect Interleukin 23 alpha (IL-23A) using this Anti-Interleukin 23 alpha (IL-23A) Antibody validated for use in WB, FC.

    merck millipore,默克密理博,06-1079,Anti-Interleukin 23 alpha (IL-23A) Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1079,Anti-Interleukin 23 alpha (IL-23A) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HFC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1079
    描述 Anti-Interleukin 23 alpha (IL-23A) Antibody
    Alternate Names
    • interleukin 23, alpha subunit p19
    • IL-23 subunit alpha
    • Interleukin-23 subunit p19
    • JKA3 induced upon T-cell activation
    • interleukin 23 p19 subunit
    背景信息 Interleukin-23 subunit alpha (IL-23A or IL-23, p19 subunit) is a subunit of heterodimeric cytokine IL-23, which also contains the p40 subunit of interleukin 12 (IL-12B). The receptor of IL-23 is formed by the beta 1 subunit of IL-12 (IL-12RB1) and an IL-23 specific subunit, IL-23R. IL-23 activates the transcription activator STAT4, and stimulates the production of interferon-gamma. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.
    产品信息
    格式 Affinity Purified
    控制
    • 3T3/A31 cell lysate
    演示 Purified rabbit polyclonal in PBS with 0.09% sodium azide.
    应用
    应用 Detect Interleukin 23 alpha (IL-23A) using this Anti-Interleukin 23 alpha (IL-23A) Antibody validated for use in WB, FC.
    主要应用
    • Flow Cytometry
    • Western Blotting
    应用说明 Flow Cytometry Analysis: 1 µg from a previous lot detected IL-23 alpha in human PBMC's.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the mature chain of human IL-23 subunit alpha.
    表位 Mature chain of IL-23, subunit alpha.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Antibody recognizes the mature chain of IL-23 subunit alpha.
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    Predicted to react with rhesus monkey based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_057668
    Entrez基因汇总 This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq].
    基因符号
    • SGRF
    • IL23A
    • IL-23
    • IL-23A
    • IL-23p19
    • IL23P19
    • P19
    纯化方法 Affinity Purfied
    UniProt编号
    • Q9NPF7
    UniProt汇总 FUNCTION: Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

    SUBUNIT STRUCTURE: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

    SUBCELLULAR LOCATION: Secreted. Note: Secreted upon association with IL12B.

    TISSUE SPECIFICTY: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

    DEVELOPMENTAL STAGE: Expressed by newborns dendritic cells.

    INDUCTION: Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.

    SEQUENCE SIMILARITIES: Belongs to the IL-6 superfamily.
    产品使用声明
    质量保证 Evaluated by Western Blot in 3T3/A31 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected IL-23 alpha in 10 µg of 3T3/A31 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1079,Anti-Interleukin 23 alpha (IL-23A) Antibody

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