- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,21-204,TOPglow (TCF reporter plasmid)
产品名称：TOPglow (TCF reporter plasmid)
产品型号：21-204
Transfection grade T cell factor (TCF) reporter plasmid containing four copies of the Tcf binding site (wt) upstream of E1B TATA box & Luciferase open reading frame.
merck millipore,默克密理博,21-204,TOPglow (TCF reporter plasmid)
- 产品介绍
描述 产品目录编号 21-204 品牌系列 Upstate
商名 - Upstate
描述 TOPglow (TCF reporter plasmid) 应用 应用 Transfection grade T cell factor (TCF) reporter plasmid containing four copies of the Tcf binding site (wt) upstream of E1B TATA box & Luciferase open reading frame. 主要应用 - Transfection
生物信息 Entrez基因编号 - NM_000545.4
Entrez基因汇总 This gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described. 基因符号 - HNF1a
- TCF1
- MODY3
- HNF1
- HNF-1A
- TCF-1
- HNF1A
- LFB1
UniProt编号 - P15884
- P20823
- P15923
UniProt汇总 FUNCTION: SwissProt: P20823 # Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
SIZE: 631 amino acids; 67356 Da
SUBUNIT: Binds DNA as a dimer.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Liver.
DISEASE: SwissProt: P20823 # Defects in HNF1A may predispose to hepatic adenomas [MIM:142330]. Hepatic adenomas are benign tumors at risk of malignant transformation. Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. & Defects in HNF1A are the cause of maturity onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY [MIM:606391] is a form of diabetes characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion. The clinical phenotype of MODY3 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications. & Defects in HNF1A are a cause of susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100].
SIMILARITY: SwissProt: P20823 ## Belongs to the HNF1 homeobox family. & Contains 1 homeobox DNA-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 5 µg
上一件merck millipore产品：merck millipore,默克密理博,17-409,EZ-Magna ChIP™ G - Chromatin Immunoprecipitation Kit
下一件merck millipore产品：merck millipore,默克密理博,6910-OP,OmniPur PIPES, Sodium Salt - CAS 100037-69-2 - Calbiochem
merck millipore,默克密理博,MAB2635,Anti-Mena Antibody, clone A351F7D9
merck millipore,默克密理博,324690,EMPIGEN BB Detergent, 30% Solution - Calbiochem
merck millipore,默克密理博,06-1079,Anti-Interleukin 23 alpha (IL-23A) Antibody
merck millipore,默克密理博,MAB3582,Anti-Fascin Antibody, clone 55K2
merck millipore,默克密理博,17-409,EZ-Magna ChIP™ G - Chromatin Immunoprecipitation Kit
merck millipore,默克密理博,6910-OP,OmniPur PIPES, Sodium Salt - CAS 100037-69-2 - Calbiochem
merck millipore,默克密理博,14-844,PIP5K1α Protein, active, 10 µg
merck millipore,默克密理博,210150,Cantharidic Acid - CAS 28874-45-5 - Calbiochem
merck millipore,默克密理博,SF-1972,CKS1B; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,373226,Hdm2 E3 Ligase Inhibitor II, HLI373 - CAS 502137-98-6 - Calbiochem