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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-923 品牌系列 Upstate
商名 - Upstate
描述 Anti-XPG Antibody, clone 8H7 产品信息 格式 Purified 应用 应用 Anti-XPG Antibody, clone 8H7 is a high quality Mouse Monoclonal Antibody for the detection of XPG & has been validated in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant human XPG. 克隆 clone 8H7 宿主 Mouse 特异性 Recognizes XPG. A non-specific protein was also detected, Mr 67kDa. 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000123
Entrez基因汇总 Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cause Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been described, but the biological validity of all variants has not been determined. 基因符号 - COFS3
- ERCC5
- XPG
- UVDR
- OTTHUMP00000064902
- ERCM2
- XPGC
纯化方法 Protein G purfied UniProt编号 - P28715
UniProt汇总 FUNCTION: SwissProt: P28715 # Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
SIZE: 1186 amino acids; 133307 Da
SUBUNIT: Interacts with PCNA.
SUBCELLULAR LOCATION: Nucleus.
DISEASE: SwissProt: P28715 # Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G) [MIM:278870]; also known as xeroderma pigmentosum VII (XP7). XP-G is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. & Defects in ERCC5 are a cause of Cockayne syndrome (CS) [MIM:216400]. CS is an autosomal recessive disease which is characterized by a UV-sensitive skin (without pigmentation abnormalities), neurological dysfunction due to demyelination of neurons and calcification of basal ganglia (psychomotor retardation, deafness, optic atrophy, retinal pigmentation and hyperreflexes), and dysmorphic dwarfism (immature sexual development and microcephaly).
SIMILARITY: SwissProt: P28715 ## Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.产品使用声明 质量保证 Routinely evaluated by immunoblot analysis. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 200 µg
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