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merck millipore,默克密理博,05-775,Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal
产品名称：Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal
产品型号：05-775
This Anti-Ha-Ras Antibody, clone MC57 is validated for use in WB for the detection of Ha-Ras.
merck millipore,默克密理博,05-775,Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Monoclonal Antibody 描述 产品目录编号 05-775 品牌系列 Upstate
商名 - Upstate
描述 Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 This Anti-Ha-Ras Antibody, clone MC57 is validated for use in WB for the detection of Ha-Ras. 主要应用 - Western Blotting
生物信息 免疫原品种 GST fusion protein corresponding to full length human Ha-Ras 宿主 Rabbit 特异性 Ha-Ras; does not cross react with Cdc42, Rho or Rac1 同种型 IgG 品种反应性 Human Species Reactivity Note Predicted to cross-react with mouse and rat based on sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005343
基因符号 - H-RasIDX
- HRAS
- Ha-Ras
- K-ras
- N-ras
- p21ras
- CTLO
- HRAS1
- c-bas/has
- H-Ras-1
- RASH1
- c-H-ras
纯化方法 Protein A purfied UniProt编号 - P01112
UniProt汇总 FUNCTION: SwissProt: P01112 # Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
SIZE: 189 amino acids; 21298 Da
SUBUNIT: In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus.
PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
DISEASE: SwissProt: P01112 # Defects in HRAS are the cause of Costello syndrome [MIM:218040]; also known as faciocutaneoskeletal syndrome. Costello syndrome is a rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities. & Mutations which change positions 12, 13 or 61 activate the potential of c-ras to transform cultured cells and are implicated in a variety of human tumors. & Defects in HRAS are a cause of bladder cancer [MIM:109800]. & Defects in HRAS are also the cause of oral squamous cell carcinoma (OSCC).
SIMILARITY: SwissProt: P01112 ## Belongs to the small GTPase superfamily. Ras family.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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