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品种反应性 主要应用 宿主 格式 抗体类型 M, H FC, IHC M Purified Monoclonal Antibody 描述 产品目录编号 04-1585 描述 Anti-IL-18 Antibody, clone 12E7.1 Alternate Names - Interferon gamma-inducing factor
- interleukin 18 (interferon-gamma-inducing factor)
- IL-1 gamma
- IFN-gamma-inducing factor
- iboctadekin
- interleukin-18
- Interleukin-1 gamma
- Iboctadekin
背景信息 IL-18 has been shown to be a pro-inflammatory cytokine that induces interferon-gamma. IL-18 has also been found to have the ability to activate nuclear factor-kappaB (NFkB), express Fas ligand, induce CC and CXC chemokines, and also has been found to increase the production of viable human immunodeficiency virus. IL-18 has been linked to syndromes displaying symptoms of chronic low-levels of inflammation. IL-18 also seems to have some control over homeostasis and behavior in the central nervous system as well as neuroinflammatory activity. 产品信息 格式 Purified 控制 - PC3 cells
演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 Anti-IL-18 Antibody, clone 12E7.1 is an antibody against IL-18 for use in IH, FC. 主要应用 - Flow Cytometry
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in human tonsil tissue.
Immunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in inflamed skin and normal human spleen tissues.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human IL-18. 克隆 12E7.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgMκ 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with human and mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001553
Entrez基因汇总 The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq]. 基因符号 - IL-1g
- IL-18
- IL18
- IGIF
- IL1F4
纯化方法 Ion Exchange UniProt编号 - Q14116
UniProt汇总 FUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the IL-1 family.产品使用声明 质量保证 Evaluated by Flow Cytometry in PC3 cells.
Flow Cytometry Analysis: 1 µg of this antibody detected IL-18 in PC3 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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