merck millipore,默克密理愽
  • merck millipore,默克密理博,05-733,Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84

  • merck millipore,默克密理博,05-733,Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84

    产品名称：Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84
    产品型号：05-733
    Detect SETA/CIN85/Ruk/SH3KBPI using this Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84 validated for use in IP, WB & IC.

    merck millipore,默克密理博,05-733,Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84

  • 产品介绍
  • merck millipore,默克密理博,05-733,Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-733
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84
    产品信息
    格式 Purified
    演示 Prtotein G purified antibody in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4
    应用
    应用 Detect SETA/CIN85/Ruk/SH3KBPI using this Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84 validated for use in IP, WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 6His and HA tagged fusion protein corresponding to full length rat SETA
    克隆 clone 84
    宿主 Mouse
    特异性 SETA
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_031892
    Entrez基因汇总 CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001 [PubMed 11474197]).[supplied by OMIM]
    基因符号
    • MIG18
    • SH3KBP1
    • CD2BP3
    • OTTHUMP00000061480
    • HSB-1
    • GIG10
    • CIN85
    纯化方法 Protein G chromatography
    UniProt编号
    • Q96B97
    UniProt汇总 FUNCTION: SwissProt: Q96B97 # Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis.
    SIZE: 665 amino acids; 73126 Da
    SUBUNIT: Can self-associate and form homotetramers. Interacts with CD2, F-actin capping protein, PIK3R3, GRB2, EGFR, MET, BLNK, MAP3K4, PDCD6IP, SPRY2, ARHGAP17, MAGI2, CRK, BCAR1, SOS1, DDEF1, CENTD3, HIP1R, SYNJ2, INPP5D and STAP1. Interacts with CBL and CBLB, but does not interact with CBLC. Two molecules of SH3KBP1 seem to bind through their respective SH3 1 domain to one molecule of CBLB. The interaction with CBL or CBLB and EGFR is increased upon EGF stimulation. The interaction with CBL is attenuated by PDCD6IP. Interacts through its proline-rich region with the SH3 domain of endophilins SH3GL1, SH3GL2 and SH3GL3. The SH3KBP1- endophilin complex seems to associate with a complex containing the phosphorylated receptor (EGFR or MET) and phosphorylated CBL. Probably associates with DDEF1 and phosphorylated EGFR. Probably part of a complex consisting of at least SH3KBP1, DDEF1 and CENTD3. Interacts with focal adhesion kinases PTK2 AND PTK2B, probably as a dimer. Interacts with DAB2 and probably associates with chathrin through its interaction with DAB2. Part of a complex consisting of SH3KBP1, DAB2, and clathrin heavy chain. DAB2 and clathrin dissociate from SH3KBP1 following growth factor treatment, enabling interaction with CBL. Interacts with DDN and probably associates with MAGI2 through its interaction with DDN. Interacts with the SH3 domains of SRC tyrosine-protein kinases SRC, LCK, LYN, FGR, FYN and HCK. Interacts with TRADD, BIRC2, TRAF1, TRAF2 and TNFR1, and the association with a TNFR1- associated complex upon stimulation with TNF-alpha seems to be mediated by SRC. Probably interacts with SH3KBP1.
    SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome; Peripheral membrane protein. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with DDEF1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity).TISSUE SPECIFICITY: Ubiquitously expressed. Also expressed in some cancer cell lines.DOMAIN:SwissProt: Q96B97 The SH3 domains mediate interaction with SHKBP1 (By similarity).
    PTM: Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.
    SIMILARITY: Contains 3 SH3 domains.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from NG108-15 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-733,Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84

上一件merck millipore产品：merck millipore,默克密理博,MABN644,Anti-LRAT Antibody, clone M34-P1F10
下一件merck millipore产品：merck millipore,默克密理博,401111,Mouse IgG, Serum


相关产品

merck millipore,默克密理博,05-23-2151,PACAP 27 Amide, Ovine - CAS 127317-03-7 - Calbiochem merck millipore,默克密理博,05-23-2151,PACAP 27 Amide, Ovine - CAS 127317-03-7 - Calbiochem

merck millipore,默克密理博,04-085,Anti-Ago family Antibody merck millipore,默克密理博,04-085,Anti-Ago family Antibody

merck millipore,默克密理博,MAB3782,Anti-p14Arf Antibody, clone 4C6/4 merck millipore,默克密理博,MAB3782,Anti-p14Arf Antibody, clone 4C6/4

merck millipore,默克密理博,ABT139,Anti-Integrin alpha8 Antibody merck millipore,默克密理博,ABT139,Anti-Integrin alpha8 Antibody

merck millipore,默克密理博,MABN644,Anti-LRAT Antibody, clone M34-P1F10 merck millipore,默克密理博,MABN644,Anti-LRAT Antibody, clone M34-P1F10

merck millipore,默克密理博,401111,Mouse IgG, Serum merck millipore,默克密理博,401111,Mouse IgG, Serum

merck millipore,默克密理博,420112,JAK3 Inhibitor, Negative Control - CAS 153437-07-1 - Calbiochem merck millipore,默克密理博,420112,JAK3 Inhibitor, Negative Control - CAS 153437-07-1 - Calbiochem

merck millipore,默克密理博,AB1603,Anti-Phosphoserine Antibody merck millipore,默克密理博,AB1603,Anti-Phosphoserine Antibody

merck millipore,默克密理博,23-026M,SCF-TrCP1 Protein Complex, Active, 250 µg merck millipore,默克密理博,23-026M,SCF-TrCP1 Protein Complex, Active, 250 µg

merck millipore,默克密理博,ABC388,Anti-FETUB Antibody merck millipore,默克密理博,ABC388,Anti-FETUB Antibody


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部