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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-647 品牌系列 Upstate
商名 - Upstate
描述 Anti-Tyrosinase Antibody, clone T311 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 This Anti-Tyrosinase Antibody, clone T311 is validated for use in WB, IH for the detection of Tyrosinase. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Not recommended for Immunoprecipitation 生物信息 免疫原品种 Purified recombinant Tyrosinase corresponding to residues 5-456 of human Tyrosinase 克隆 T311 宿主 Mouse 特异性 Tyrosinase 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000372
基因符号 - OCA1A
- TYR
- LB24-AB
- tyrosinase
- OCAIA
- SK29-AB
纯化方法 Protein G chromatography UniProt编号 - P14679
UniProt汇总 FUNCTION: SwissProt: P14679 # This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
COFACTOR: Binds 2 copper ions per subunit.
SIZE: 529 amino acids; 60393 Da
SUBCELLULAR LOCATION: Melanosome membrane; Single-pass type I membrane protein.
DISEASE: SwissProt: P14679 # Defects in TYR are the cause of oculocutaneous albinism type IA (OCA-IA) [MIM:203100]. OCA-I, also known as tyrosinase negative oculocutaneous albinism, is an autosomal recessive disorder characterized by absence of pigment in hair, skin and eyes. OCA-I is divided into 2 types: type IA, characterized by complete lack of tyrosinase activity due to production of an inactive enzyme, and type IB characterized by reduced activity of tyrosinase. OCA-IA patients presents with the life-long absence of melanin pigment after birth and manifest increased sensitivity to ultraviolet radiation and to predisposition to skin cancer. & Defects in TYR are the cause of oculocutaneous albinism type IB (OCA-IB) [MIM:606952]; also known as albinism yellow mutant type. OCA-IB patients have white hair at birth that rapidly turns yellow or blond. They manifest the development of minimal- to-moderate amounts of cutaneous and ocular pigment. & Defects in TYR are the cause of oculocutaneous albinism type I temperature-sensitive (OCA-ITS) [MIM:606952]. OCA-ITS patients have white axillary and scalp hair and pigmented arm and leg hair.
SIMILARITY: SwissProt: P14679 ## Belongs to the tyrosinase family.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from SK-MEL-19 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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