merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1056,Anti-Neutrophil Elastase Antibody, clone AHN-10

  • merck millipore,默克密理博,MAB1056,Anti-Neutrophil Elastase Antibody, clone AHN-10

    产品名称：Anti-Neutrophil Elastase Antibody, clone AHN-10
    产品型号：MAB1056
    Anti-Neutrophil Elastase Antibody, clone AHN-10 detects level of Neutrophil Elastase & has been published & validated for use in IP, RIA & IC.

    merck millipore,默克密理博,MAB1056,Anti-Neutrophil Elastase Antibody, clone AHN-10

  • 产品介绍
  • merck millipore,默克密理博,MAB1056,Anti-Neutrophil Elastase Antibody, clone AHN-10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB1056
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Neutrophil Elastase Antibody, clone AHN-10
    产品信息
    格式 Ascites
    应用
    应用 Anti-Neutrophil Elastase Antibody, clone AHN-10 detects level of Neutrophil Elastase & has been published & validated for use in IP, RIA & IC.
    主要应用
    • Immunocytochemistry
    应用说明 Immunoprecipitation

    Immunocytochemistry

    RIA

    Optimal working dilutions must be determined by end user.
    生物信息
    克隆 AHN-10
    宿主 Mouse
    特异性 Reacts specifically with human neutrophil elastase and not with the 3 homologous neutrophil neutral serine proteases, cathepsin G, esterase N and proteinase 3. Inhibits the elastinolytic activity of elastase. Elastase is felt to play an important role in a number of disease states.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001972.2
    Entrez基因汇总 Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Elastase 2 hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
    基因符号
    • EC 3.4.21.37
    • ELA2
    • HLE
    • GE
    • PMN-E
    • SERP1
    • Elastase-2
    • medullasin
    • NE
    • Medullasin
    • HNE
    UniProt编号
    • P08246
    UniProt汇总 FUNCTION: SwissProt: P08246 # Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
    SIZE: 267 amino acids; 28518 Da
    TISSUE SPECIFICITY: Bone marrow cells.
    DISEASE: SwissProt: P08246 # Defects in ELA2 are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.
    SIMILARITY: SwissProt: P08246 ## Belongs to the peptidase S1 family. Elastase subfamily. & Contains 1 peptidase S1 domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain in convenient aliquots at -20°C or colder for up to 12 months. Avoid thawing and refreezing.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB1056,Anti-Neutrophil Elastase Antibody, clone AHN-10

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