merck millipore,默克密理愽
  • merck millipore,默克密理博,14-481M,PAK2 Protein, active, 250 µg

  • merck millipore,默克密理博,14-481M,PAK2 Protein, active, 250 µg

    产品名称：PAK2 Protein, active, 250 µg
    产品型号：14-481M
    Active, recombinant human PAK2, residues 3-end, containing N-terminal His6 & T7 & C-terminal His6 tags, for use in Kinase Assays.

    merck millipore,默克密理博,14-481M,PAK2 Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-481M,PAK2 Protein, active, 250 µg

    描述
    产品目录编号 14-481M
    品牌系列 Upstate
    商名
    • Upstate
    描述 PAK2 Protein, active, 250 µg
    概述 Recombinant human PAK2, residues 3-end, containing N-terminal His6 and T7, and C-terminal His6 tags
    应用
    应用 Active, recombinant human PAK2, residues 3-end, containing N-terminal His6 & T7 & C-terminal His6 tags, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed in E. coli
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002577.3
    Entrez基因汇总 The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
    基因符号
    • PAK-2
    • PAK2
    • PAK65
    • Gamma-PAK
    • hPAK65
    • PAKgamma
    蛋白靶 PAK2
    纯化方法 Ni2+/NTA-agarose
    靶子系列 STE
    UniProt编号
    • Q13177
    UniProt汇总 FUNCTION: SwissProt: Q13177 # The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase- activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form.
    SIZE: 524 amino acids; 58043 Da
    SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with and activated by HIV-1 Nef. PAK-2p34 interacts with ARHGAP10.
    SUBCELLULAR LOCATION: Serine/threonine-protein kinase PAK 2: Cytoplasm. & PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
    TISSUE SPECIFICITY: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
    PTM: Full length PAK 2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK- 2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate. & During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34. & Ubiquitinated, leading to its proteosomal degradation. & PAK-2p34 is myristoylated.
    SIMILARITY: SwissProt: Q13177 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of the Long S6 Kinase substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70 °C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-481) and in bulk (cat# 14-481-K).

    merck millipore,默克密理博,14-481M,PAK2 Protein, active, 250 µg

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