merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1559,Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2

  • merck millipore,默克密理博,05-1559,Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2

    产品名称：Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2
    产品型号：05-1559
    Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2 detects level of PI3 Kinase & has been published & validated for use in WB & IC.

    merck millipore,默克密理博,05-1559,Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2

  • 产品介绍
  • merck millipore,默克密理博,05-1559,Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1559
    Replaces 04-402
    描述 Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2
    Alternate Names
    • phosphatidylinositol 3 kinase gamma, p110 gamma
    • phosphoinositide-3-kinase, catalytic, gamma polypeptide
    • phosphoinositide-3-kinase gamma catalytic subunit
    • PtdIns-3-kinase subunit p110-gamma
    • phosphatidylinositol 3-kinase catalytic 110-kD gamma
    • Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
    • PtdIns-3-kinase subunit gamma
    • p110-gamma
    • PI3-kinase subunit gamma
    • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    • PI3K-gamma
    • 1-phosphatidylinositol 3-kinase
    • PI3Kgamma
    • phosphatidylinositol 3-kinase, catalytic, gamma polypeptide
    背景信息 PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival, signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β:γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.
    产品信息
    格式 Purified
    控制
    • K562 cell lysate
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2 detects level of PI3 Kinase & has been published & validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected PI3 Kinase, p110γ in A431 cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human PI3 Kinase, p110γ.
    克隆 17D7.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgMκ
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002640
    Entrez基因汇总 This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq].
    基因符号
    • PIK3CG
    • PI3CG
    • p120-PI3K
    • PIK3
    • PI3K
    纯化方法 Ion Exchange
    UniProt编号
    • P48736
    UniProt汇总 FUNCTION: 3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.

    CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

    ENZYME REGULATION: Activated by both the alpha and the beta-gamma G proteins.

    PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

    SUBUNIT STRUCTURE: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.

    TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.

    SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family.

    Contains 1 PI3K/PI4K domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in K562 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected PI3 Kinase, p110γ on 10 µg of K562 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1559,Anti-PI3 Kinase Antibody, p110γ, clone 17D7.2

上一件merck millipore产品：merck millipore,默克密理博,05-581,Anti-CFTR Antibody, clone MM13-4
下一件merck millipore产品：merck millipore,默克密理博,05-727,Anti-Rsf-1 Antibody, clone 5H2/E4


相关产品

merck millipore,默克密理博,MAB2060,Anti-Integrin β4 Antibody, clone ASC-9 merck millipore,默克密理博,MAB2060,Anti-Integrin β4 Antibody, clone ASC-9

merck millipore,默克密理博,MABN689,Anti-ARHGDIA Antibody, clone 2G3 merck millipore,默克密理博,MABN689,Anti-ARHGDIA Antibody, clone 2G3

merck millipore,默克密理博,SF-1393,ATR; Human, Cyanine 5 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1393,ATR; Human, Cyanine 5 RNA Detection Probe,SmartFlare

merck millipore,默克密理博,06-1367,Anti-SRp75 Antibody merck millipore,默克密理博,06-1367,Anti-SRp75 Antibody

merck millipore,默克密理博,05-581,Anti-CFTR Antibody, clone MM13-4 merck millipore,默克密理博,05-581,Anti-CFTR Antibody, clone MM13-4

merck millipore,默克密理博,05-727,Anti-Rsf-1 Antibody, clone 5H2/E4 merck millipore,默克密理博,05-727,Anti-Rsf-1 Antibody, clone 5H2/E4

merck millipore,默克密理博,05-647,Anti-Tyrosinase Antibody, clone T311 merck millipore,默克密理博,05-647,Anti-Tyrosinase Antibody, clone T311

merck millipore,默克密理博,0500-0300,Guava PCA Advanced Assay Suite (5+ Modules) merck millipore,默克密理博,0500-0300,Guava PCA Advanced Assay Suite (5+ Modules)

merck millipore,默克密理博,14-481M,PAK2 Protein, active, 250 µg merck millipore,默克密理博,14-481M,PAK2 Protein, active, 250 µg

merck millipore,默克密理博,MAB1056,Anti-Neutrophil Elastase Antibody, clone AHN-10 merck millipore,默克密理博,MAB1056,Anti-Neutrophil Elastase Antibody, clone AHN-10


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部