merck millipore,默克密理愽
  • merck millipore,默克密理博,05-615,Anti-SUV39H1 Antibody, clone MG44

  • merck millipore,默克密理博,05-615,Anti-SUV39H1 Antibody, clone MG44

    产品名称：Anti-SUV39H1 Antibody, clone MG44
    产品型号：05-615
    Anti-SUV39H1 Antibody, clone MG44 is a Mouse Monoclonal Antibody for detection of SUV39H1 also known as KMT1A, Histone H3-K9 Methyltransferase 1 & has been validated in ChIP, IP & WB.

    merck millipore,默克密理博,05-615,Anti-SUV39H1 Antibody, clone MG44

  • 产品介绍
  • merck millipore,默克密理博,05-615,Anti-SUV39H1 Antibody, clone MG44

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBMAscitesMonoclonal Antibody
    描述
    产品目录编号 05-615
    Replaces MABE552
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-SUV39H1 Antibody, clone MG44
    Alternate Names
    • KMT1A
    背景信息 Post -translational modification of histones, such as phosphorylation, acetylation, and methylation, are crucial for chromatin remodeling. SUV39H1 and Suv39h1 are the human and mouse homologs of Drosophila Su(var)3-9 protein, respectively. These proteins selectively methylate histone H3 at lysine 9 creating a high-affinity binding site for the HP1 proteins (heterochromatin protein 1). HP1 proteins are known to interact with transcription suppressor proteins, suggesting that the interactions with SUV39H1 and methylated histone H3 mediate a silence effect on the transcription of target genes. Furthermore, over-expression of SUV39H1 in HeLa cells causes a redistribution of endogenous HP1 proteins and growth retardation, suggesting that SUV39H1-mediated modulation of heterochromatin can impair cell cycle progression.
    产品信息
    格式 Ascites
    控制
    • U2OS cell lysate
    演示 Protein G Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
    应用
    应用 Anti-SUV39H1 Antibody, clone MG44 is a Mouse Monoclonal Antibody for detection of SUV39H1 also known as KMT1A, Histone H3-K9 Methyltransferase 1 & has been validated in ChIP, IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 MBP fusion protein corresponding to residues 1-412 of human SUV39H1
    克隆 MG44
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes SUV39H1.
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003173.2
    Entrez基因汇总 This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
    基因符号
    • MG44
    • SUV39H1
    • Su
    • SUV39H
    纯化方法 Unpurified
    UniProt编号
    • O43463
    UniProt汇总 FUNCTION: SwissProt: O43463 # Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiaton, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length.

    SIZE: 412 amino acids; 47907 Da

    SUBUNIT: Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR.

    SUBCELLULAR LOCATION: Nucleus. Note=Associates with centromeric constitutive heterochromatin.

    DEVELOPMENTAL STAGE: Accumulates during mitosis at centromeres during prometaphase, but dissociates from the centromere at the meta- to anaphase transition.

    DOMAIN: SwissProt: O43463 Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin.

    PTM: Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilized by SBF1 and is less active in its transcriptional repressor function.

    SIMILARITY: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. & Contains 1 chromo domain. & Contains 1 post-SET domain. & Contains 1 pre-SET domain. & Contains 1 SET domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on U2OS cells lysed in RIPA with 0.1% SDS and sonicated
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,05-615,Anti-SUV39H1 Antibody, clone MG44

上一件merck millipore产品：merck millipore,默克密理博,ABT358,Anti-TGFBI Antibody
下一件merck millipore产品：merck millipore,默克密理博,0500-0290,Guava Flow Cell (PCA-96/EasyCyte Systems)


相关产品

merck millipore,默克密理博,AB1528,Anti-Nerve Growth Factor-β Antibody merck millipore,默克密理博,AB1528,Anti-Nerve Growth Factor-β Antibody

merck millipore,默克密理博,MABN690,Anti-PPP1CA Antibody, clone 5E9 merck millipore,默克密理博,MABN690,Anti-PPP1CA Antibody, clone 5E9

merck millipore,默克密理博,324628,EGTA/AM - CAS 99590-86-0 - Calbiochem merck millipore,默克密理博,324628,EGTA/AM - CAS 99590-86-0 - Calbiochem

merck millipore,默克密理博,IF007,Interferon-α A Protein, Recombinant human merck millipore,默克密理博,IF007,Interferon-α A Protein, Recombinant human

merck millipore,默克密理博,ABT358,Anti-TGFBI Antibody merck millipore,默克密理博,ABT358,Anti-TGFBI Antibody

merck millipore,默克密理博,0500-0290,Guava Flow Cell (PCA-96/EasyCyte Systems) merck millipore,默克密理博,0500-0290,Guava Flow Cell (PCA-96/EasyCyte Systems)

merck millipore,默克密理博,70550,T7Select10-3 Cloning Kit merck millipore,默克密理博,70550,T7Select10-3 Cloning Kit

merck millipore,默克密理博,MAB4423C3,Anti-SOX-2 Antibody, clone 10H9.1, Cy3 conjugate merck millipore,默克密理博,MAB4423C3,Anti-SOX-2 Antibody, clone 10H9.1, Cy3 conjugate

merck millipore,默克密理博,345885,GGTI-2147 - CAS 191102-87-1 - Calbiochem merck millipore,默克密理博,345885,GGTI-2147 - CAS 191102-87-1 - Calbiochem

merck millipore,默克密理博,HTS193M,ChemiSCREEN™ Membrane Preparation Recombinant Human S1P5 Lysophospholipid Receptor merck millipore,默克密理博,HTS193M,ChemiSCREEN™ Membrane Preparation Recombinant Human S1P5 Lysophospholipid...


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部