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merck millipore,默克密理博,345885,GGTI-2147 - CAS 191102-87-1 - Calbiochem
产品名称：GGTI-2147 - CAS 191102-87-1 - Calbiochem
产品型号：345885
A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).
merck millipore,默克密理博,345885,GGTI-2147 - CAS 191102-87-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₈H₃₀N₄O₃ 191102-87-1 描述 概述 A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50 value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 > 30 µM for H-Ras). 产品目录编号 345885 品牌系列 Calbiochem®
同义词 4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester 参考 参考 Bernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.产品信息 CAS号 191102-87-1 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₂₈H₃₀N₄O₃ 化学配方 C₂₈H₃₀N₄O₃ Molar Mass 470.6 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 GGTase-I 主靶IC50 500 nM in blocking the geranyl-geranylation of Rap1A 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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