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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, Ch, H, M IHC, ELISA, WB Sh Serum Polyclonal Antibody 描述 产品目录编号 AB1528 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Nerve Growth Factor-β Antibody Alternate Names - NGFbeta
产品信息 格式 Serum 演示 Whole sheep antisera. Lyophilized. Reconstitute with 250 μL of sterile distilled water. 应用 应用 Detect Nerve Growth Factor-β using this Anti-Nerve Growth Factor-β Antibody validated for use in ELISA, WB, IH. 主要应用 - Immunohistochemistry
- ELISA
- Western Blotting
应用说明 Immunohistochemistry at 1:500-1:5,000 (see suggested protocol).
Immunoblotting at 1:500-1:5,000.
ELISA at 1:500-1:5,000.
Inhibition of biological activity in vitro at 1:10-1:50.
BIOLOGICAL ACTIVITY: Neutralizes NGF, but not other neurotrophins.
Use neat for in vivo animal studies (5-10 μL/g body weight).
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Mouse nerve growth factor-beta purified from salivary glands. 宿主 Sheep 特异性 Nerve growth factor-beta (NGF). Less than 1% cross-reactivity against recombinant human NT4 and BDNF and approximately 2% for NT3 by ELISA. 品种反应性 RatChickenHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002506.2
Entrez基因汇总 This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. 基因符号 - MGC161428
- NGFB
- MGC161426
- HSAN5
- NGF
- Beta-NGF
非反应性品种 - Bovine
UniProt编号 - P01138
UniProt汇总 FUNCTION: SwissProt: P01138 # Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.
SIZE: 241 amino acids; 26959 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
DISEASE: SwissProt: P01138 # Defects in NGFB are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. Hereditary sensory and autonomic neuropathies are characterized by loss of pain sensation in combination with other sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self- mutilation. The autonomic involvement is variable.
SIMILARITY: SwissProt: P01138 ## Belongs to the NGF-beta family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C to -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 250 µL
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