merck millipore,默克密理愽
  • merck millipore,默克密理博,361550,GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

  • merck millipore,默克密理博,361550,GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

    产品名称：GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem
    产品型号：361550
    The GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic More>>

    merck millipore,默克密理博,361550,GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,361550,GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₀BrN₃O₂667463-62-9
    描述
    概述 A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available.
    产品目录编号 361550
    品牌系列 Calbiochem®
    同义词 BIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
    参考
    参考 Tseng, A-S., et al. 2006. Chem. Biol. 13, 957.
    Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
    Sato, N., et al. 2004. Nat. Med. 10, 55.
    Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
    产品信息
    CAS号 667463-62-9
    具有ATP竞争性 Y
    形式 Purple solid
    Hill配方 C₁₆H₁₀BrN₃O₂
    化学配方 C₁₆H₁₀BrN₃O₂
    Molar Mass 356.2
    可逆 Y
    结构配方图像
    生物信息
    主靶 GSK-3α/β
    主靶IC50 5 nM against GSK-3α/β
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    安全信息
    R相 R: 20/21/22

    Harmful by inhalation, in contact with skin and if swallowed.
    S相 S: 22-36/37

    Do not breathe dust.
    Wear suitable protective clothing and gloves.
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,361550,GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

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