merck millipore,默克密理博,05-23-0101,Angiotensin II, Human - CAS 4474-91-3

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Merck Millipore 默克密理愽

merck millipore,默克密理博,05-23-0101,Angiotensin II, Human - CAS 4474-91-3 - Calbiochem

经验配方	CAS号
C₅₀H₇₁N₁₃O₁₂	4474-91-3

描述
概述	Plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca²⁺ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K⁺ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125^FAKand a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60^c-src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.
产品目录编号	05-23-0101
品牌系列	Calbiochem®
同义词	DRVYIHPF

参考
参考	Zhu, M., et al. 2000. J. Neurophysiol. 84, 2494. Natarajan, R., et al. 1999. Hypertension 33, 378. Mazzolai, L., et al. 1998. Hypertension 31, 1324. Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440. Ishida, M., et al. 1995. Circ. Res. 77, 1053. Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

产品信息
CAS号	4474-91-3
具有ATP竞争性	N
形式	White to off-white solid
Hill配方	C₅₀H₇₁N₁₃O₁₂
化学配方	C₅₀H₇₁N₁₃O₁₂
Molar Mass	1046.2
吸湿	Hygroscopic
肽序列	H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
可逆	N
基于肽含量售出	Yes

生物信息
主靶	adenylate cyclase activity
纯度	≥98% by HPLC

理化信息
细胞可渗透	N
溶解度	H₂O or 5% Acetic Acid
肽含量	Yes
肽序列	H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

GHS安全信息
RTECS	BW2165000

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

merck millipore,默克密理博,05-23-0101,Angiotensin II, Human - CAS 4474-91-3 - Calbiochem

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