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merck millipore,默克密理博,06-1376,Anti-SLBP Antibody
产品名称：Anti-SLBP Antibody
产品型号：06-1376
Use Anti-SLBP Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect SLBP also known as Histone stem-loop-binding protein, HBP, Histone RNA hairpin-binding protein.
merck millipore,默克密理博,06-1376,Anti-SLBP Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 06-1376 描述 Anti-SLBP Antibody Alternate Names - Histone RNA hairpin-binding protein
- Histone stem-loop-binding protein
- hairpin binding protein
- histone binding protein 2
- histone stem-loop binding protein
- stem-loop (histone) binding protein
- stem-loop binding protein
- HBP
背景信息 The SLPB gene (stem-loop binding protein) encodes a protein that binds to the stem-loop structure of replication-dependent histone pre-mRNAs. Histone mRNA lack a polyadenylation signal. Consequently, the interaction of this protein with histone pre-mRNA contributes to efficient 3' end processing by stabilizing the complex between the pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Expression of this protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.
产品信息 格式 Serum 控制 - C2C12 cell lysates.
演示 Serum in buffer containing 0.05% sodium azide 应用 应用 Use Anti-SLBP Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect SLBP also known as Histone stem-loop-binding protein, HBP, Histone RNA hairpin-binding protein. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry:
Representative lot data.
Confocal fluorescent analysis of NIH/3T3 cells using 06-1376 (Red). Actin filaments have been labeled with AlexaFluor®488 -Phalloidin (Green). Nucleus is stained with DAPI (Blue). This antibody positively stains cytoplasm and nucleus.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human SLBP. 表位 C-terminus 宿主 Rabbit 特异性 Antibody recognizes SLBP. 品种反应性 RatHumanMouse Species Reactivity Note Reacts with Human and Mouse. Predicted to react with Rat based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_009193
Entrez基因汇总 This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq] 基因符号 - SLBP
纯化方法 Unpurified UniProt编号 - P97440
UniProt汇总 FUNCTION:Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3' end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Could play an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression By similarity.
SUBUNIT STRUCTURE:: Monomer. SLBP/pre-mRNA complex interacts with ZNF473. Interacts with MIF4GD By similarity.
SUBCELLULAR LOCATION:: Cytoplasm. Nucleus. Note: Polyribosome-associated.
TISSUE SPECIFICITY: Widely expressed.
SEQUENCE SIMILARITIES: Belongs to the SLBP family.产品使用声明 质量保证 Evaluated by Western Blotting in C2C12 cell lysates.
Western Blotting Analysis: A 1:1000 dilution of this antibody detected SLBP in C2C12 cell lysates.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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