merck millipore,默克密理愽
  • merck millipore,默克密理博,07-2126,Anti-phospho-FOXO1 Antibody (Thr24)

  • merck millipore,默克密理博,07-2126,Anti-phospho-FOXO1 Antibody (Thr24)

    产品名称：Anti-phospho-FOXO1 Antibody (Thr24)
    产品型号：07-2126
    Use Anti-phospho-FOXO1 (Thr24) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-FOXO1 (Thr24) also known as Forkhead box protein O1.

    merck millipore,默克密理博,07-2126,Anti-phospho-FOXO1 Antibody (Thr24)

  • 产品介绍
  • merck millipore,默克密理博,07-2126,Anti-phospho-FOXO1 Antibody (Thr24)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2126
    描述 Anti-phospho-FOXO1 Antibody (Thr24)
    Alternate Names
    • Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma
    背景信息 Forkhead box O (FOXO) transcription factors play an important role in modulating metabolic functions and cell proliferation. Given the relatively high expression of FOXO1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism. When nutrient and insulin levels are low, FOXO1 promotes expression of gluconeogenic enzymes. Conversely, in the fed state, insulin levels rise and stimulate uptake of glucose primarily into skeletal muscle and other organs, including adipose tissue. Under certain pathophysiologic conditions, including insulin resistance, negative signaling to FOXO1 is compromised. Increased cell proliferation occurs when FOXO1 is inactivated when phosphorylated by Akt at Thr24.
    产品信息
    格式 Affinity Purified
    控制
    • HEK293 cell lysate untreated and BMP2-treated
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-phospho-FOXO1 (Thr24) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-FOXO1 (Thr24) also known as Forkhead box protein O1.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human FOXO1 phosphorylated at Thr24.
    表位 Phosphorylated Thr24
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes FOXO1 phosphorylated at Thr24.
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_002006
    基因符号
    • FKHR
    • FOXO1
    • FOXO1A
    修改
    • Phosphorylation
    纯化方法 Affinity Purified
    UniProt编号
    • Q12778
    UniProt汇总 Function: Transcription factor which acts as a regulator of cell responses to oxidative stress. In the presence of KIRT1, mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence.

    Subunit structure: Interacts with LRPPRC. Interacts with SIRT1 and this interaction requires the presence of KRIT1.

    Subcellular location: Cytoplasm. Nucleus. Note: Shuttles between cytoplasm and nucleus.

    Tissue specificity: Ubiquitous.

    Induction: Expression is regulated by KRIT1.

    Post-translational modification: Phosphorylated by AKT1; insulin-induced. IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.

    Involvement in disease: Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=Chromosomal aberrations involving FOXO1 are found in rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.

    Sequence similarities: Contains 1 fork-head DNA-binding domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HEK293 cell lysate untreated and BMP2-treated.

    Western Blot Analysis: 2 µg/mL of this antibody detected phospho-FOXO1 (Thr24) in HEK293 cell lysate untreated and BMP2-treated.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-2126,Anti-phospho-FOXO1 Antibody (Thr24)

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