merck millipore,默克密理博,FCMAB103AP,Milli-Mark Anti-Ki67 Antibody, clone Ki-S5 APC conjugate

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, FC, ICC	M	APC	Monoclonal Antibody

描述
产品目录编号	FCMAB103AP
商名	Milli-Mark
描述	Milli-Mark Anti-Ki67 Antibody, clone Ki-S5 APC conjugate
Alternate Names	MKI67 <br />KIA <br />Ki-67
背景信息	Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a marker of cell cycling and proliferation. This specificity of Ki-S5 antibody for proliferating cells might make it a useful tool for determination of the proliferative fraction in tumors such as Non-Hodgkin's lymphoma (Kreipe et al., 1993), mammary carcinomas (Mauri et al., 1984), ovarian tumors (Ballin et al., 1994) and prostate cancer.

产品信息
格式	APC
控制	Stimulated Jurkat Cells
演示	Purified mouse monoclonal IgG1 conjugated to Allophycocyanin (APC) in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	Detect Ki67 using this Milli-Mark Anti-Ki67 Antibody, clone Ki-S5 APC conjugate validated for use in FC, IC, IH, FC, IH(P).
主要应用	Immunohistochemistry Flow Cytometry Immunocytochemistry

生物信息
免疫原品种	Nuclear protein preparation from the human cell line U937.50
克隆	Ki-S5
宿主	Mouse
特异性	Antibody recognizes Ki67.
同种型	IgG1
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_002417.3
基因符号	Ki-67 MKI67 KIA
纯化方法	Protein A purfied
UniProt编号	P46013
UniProt汇总	FUNCTION: SwissProt: P46013 # Thought to be required for maintaining cell proliferation. SIZE: 3256 amino acids; 358694 Da SUBUNIT: Binds through the FHA domain to MKI67IP. SUBCELLULAR LOCATION: Nucleus. Note=Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes. DEVELOPMENTAL STAGE: Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected. SIMILARITY: SwissProt: P46013 ## Contains 1 FHA domain. ... hide » see more »

产品使用声明
质量保证	Evaluated by Flow Cytometry with Jurkat cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8oC in undiluted aliquots for up to 6 months from date of receipt. Protect from light.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB103AP,Milli-Mark Anti-Ki67 Antibody, clone Ki-S5 APC conjugate

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