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描述 产品目录编号 14-540M 品牌系列 Upstate
商名 - Upstate
描述 Tie2 Protein, active, 250 µg 概述 N-terminal His6-tagged recombinant human Tie2 residues 771-end 应用 应用 Active, N-terminal His6-tagged recombinant human Tie2 residues 771-end, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_000459.2
Entrez基因汇总 The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. 基因符号 - TIE-2
- TEK
- CD202B
- TIE2
- VMCM1
- VMCM
- hTIE2
- CD202b
蛋白靶 Tie2 纯化方法 Ni2+/NTA-agarose 靶子系列 TK UniProt编号 - Q02763
UniProt汇总 FUNCTION: SwissProt: Q02763 # This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
SIZE: 1124 amino acids; 125811 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
DISEASE:SwissProt: Q02763 # Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated, serpiginous channels.
SIMILARITY: SwissProt: Q02763 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. & Contains 3 EGF-like domains. & Contains 3 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-540) and in bulk (cat# 14-540-K).
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