merck millipore,默克密理博,04-348,Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal

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merck millipore,默克密理博,04-348,Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal
产品名称：Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal
产品型号：04-348
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.

merck millipore,默克密理博,04-348,Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-348,Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	FC, WB, ICC	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-348
描述	Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal
Alternate Names	receptor tyrosine-protein kinase erbB-4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) Proto-oncogene-like protein c-ErbB-4 Tyrosine kinase-type cell surface receptor HER4 v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
背景信息	HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The ErbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

产品信息
格式	Unpurified
控制	MCF-7 cell lysate
演示	Rabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Flow Cytometry Western Blotting Immunocytochemistry
应用说明	Immunocytochemistry Analysis: A 1:50 dilution from a representative lot was used in IC. Immunoprecipitation Analysis: A 1:100 dilution from a representative lot was used in IP. Flow Cytometry Analysis: A 1:40 dilution from a representative lot was used in FC.

生物信息
免疫原品种	Synthetic peptide corresponding to the C-terminus of human HER4/ErbB4. The antibody does not cross-react with other EGF receptor family members.
表位	C-terminus
克隆	E200
宿主	Rabbit
同种型	IgG
品种反应性	RatHumanMouse
Species Reactivity Note	Demonstrated to react with Human, Mouse, and Rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	Q15303
基因符号	EC 2.7.10 HER4 p180erbB4 EC 2.7.10.1 MGC138404 OTTHUMP00000163968 OTTHUMP00000206623 OTTHUMP00000209432
纯化方法	Unpurified
UniProt编号	Q15303

产品使用声明
质量保证	Evaluated by Western Blot in MCF-7 cell lysate. Western Blot Analysis: A 1:4,000 dilution of this antibody detected HER4/ErbB4 in MCF-7 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.