merck millipore,默克密理博,04-1132,Anti-Rsk4 (NT) Antibody, clone EP1982Y, rabbit monoclonal

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merck millipore,默克密理博,04-1132,Anti-Rsk4 (NT) Antibody, clone EP1982Y, rabbit monoclonal
产品名称：Anti-Rsk4 (NT) Antibody, clone EP1982Y, rabbit monoclonal
产品型号：04-1132
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Rsk4 (N-term) Antibody, clone EP1982Y, Rab More>>

merck millipore,默克密理博,04-1132,Anti-Rsk4 (NT) Antibody, clone EP1982Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1132,Anti-Rsk4 (NT) Antibody, clone EP1982Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	FC, WB, ICC	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1132
描述	Anti-Rsk4 (NT) Antibody, clone EP1982Y, rabbit monoclonal
Alternate Names	ribosomal protein S6 kinase, 90kDa, polypeptide 6 90 kDa ribosomal protein S6 kinase 6 Ribosomal S6 kinase 4 S6K-alpha 6 p90-RSK 6 ribosomal protein S6 kinase polypeptide 6 ribosomal protein S6 kinase, 90kD, polypeptide 6
背景信息	Rsk1, Rsk2, Rsk3, and Rsk4 (ribosomal protein S6 kinase, 90 kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases. Following activation, Rsk isoforms translocate to the nucleus, where Rsk2 phosphorylates Ser10 of Histone H3, a critical step in the stimulation of immediate-early gene expression. Rsk1 is able to phosphorylate Ser133 of CREB, activating it as a transcription factor. RSK4 is mostly expressed in brain and kidney.

产品信息
格式	Unpurified
控制	SHSY5Y cell lysate
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Rsk4 (N-term) Antibody, clone EP1982Y, Rabbit is validated for use in WB, IC, IH(P), FC for the detection of Rsk4 (N-term).
主要应用	Flow Cytometry Western Blotting Immunocytochemistry
应用说明	Immunohistochemistry Analysis: A 1:50-100 dilution from a previous lot detected Rsk4 in human brain glioma tissue. Immunocytochemistry Analysis: A 1:100-250 dilution from a previous lot detected Rsk4 in SHSY5Y cells. Flow Cytometry: A 1:25 dilution of a previous lot was used in flow cytometry.

生物信息
免疫原品种	Synthetic peptide corresponding to residues near the N-terminus of human Rsk4.
表位	N-terminus
克隆	EP1982Y
宿主	Rabbit
特异性	This antibody recognizes Rsk4.
同种型	IgG
品种反应性	MouseHuman
Species Reactivity Note	Human and mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_055311.1
Entrez基因汇总	This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways.
基因符号	pp90RSK4 EC 2.7.11.1 OTTHUMP00000023618 PP90RSK4 RSK-4 RSK4
纯化方法	Unpurified
UniProt编号	Q9UK32
UniProt汇总	FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium By similarity. ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues By similarity. SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation By similarity. PTM: Autophosphorylated on Ser-389, as part of the activation process By similarity. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains.

产品使用声明
质量保证	Evaluated by Western Blot on SHSY5Y cell lysates. Western Blot Analysis: A 1:250-500 dilution of this antibody was used to detect Rsk4 in SHSY5Y cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.