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品种反应性 主要应用 宿主 格式 抗体类型 Eq, R, M, B, Ca WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB10223 描述 Anti-Scirr1 Antibody Alternate Names - chromosome 16 open reading frame 22
- F-box and leucine-rich repeat protein 16
- c380A1.1 (novel protein)
背景信息 Spinal cord injury and regeneration involves transcriptional activity of many genes, of which many remain unknown. In an experiment by Tau Liu, et al. one such differentially expressed gene, termed scirr1 (spinal cord injury and/or regeneration related gene 1) was found to act temporally and spatially in accordance with the early development sequence of the central nervous system. Although the precise function of SCIRR1 is unknown, its unique pattern of expression during early development of the CNS and up-regulation after spinal cord injury suggest that SCIRR1 should be involved in the succeeding injury and/or repair processes of the injured spinal cord. Also, the typical F-box and leucine-rich repeat (LRR) architecture of rat SCIRR1 indicate that it may play an important substrate recruiting role in the pleiotropic ubiquitin/proteasome pathway. All these make scirr1 a new interesting start to study the spinal cord injury and regeneration mechanism. 产品信息 格式 Affinity Purified 控制 - Rat Spinal Cord, E16 lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-Scirr1 Antibody is validated for use in WB for the detection of Scirr1. 主要应用 - Western Blotting
应用说明 Western Blot (SNAP ID) Analysis: 1:250 dilution from a previous lot detected Scirr1 on 10 µg of rat spinal cord, E16 lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the internal domain of rat Scirr1. 表位 Internal 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the internal domain of Scirr1. 品种反应性 HorseRatMouseBovineCanine Species Reactivity Note Demonstrated to react with rat and mouse. Predicted to react with cow, dog, and horse based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001009504
基因符号 - Fbl16
- Scirr1
- FBXL16
- C16orf22
- FBL16
纯化方法 Affinity Purfied UniProt编号 - Q5MJ12
UniProt汇总 FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.
SUBUNIT STRUCTURE: Interacts with SKP1A and CUL1 By similarity.
SEQUENCE SIMILARITIES: Contains 1 F-box domain.
Contains 7 LRR (leucine-rich) repeats.产品使用声明 质量保证 Evaluated by Western Blot in rat spinal cord, E16 lysate.
Western Blot Analysis: A 1:2,500 dilution of this antibody detected Scirr1 in 10 µg of rat spinal cord, E16 lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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