merck millipore,默克密理博,GF004,Granulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant human

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Merck Millipore 默克密理愽

主要应用	品种	来源	纯度
CULT	Human	E.coli	Greater than 98% by SDS-PAGE analysis.

描述
产品目录编号	GF004
品牌系列	Chemicon®
商名	Chemicon
描述	Granulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant human
概述	eGranulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a potent species-specific stimulator of bone marrow cells. GM-CSF stimulates precursor cells of granulocytes, macrophages and eosinophils. Human GM-CSF is a 14 kDa protein containing 128 amino acids residues.
Alternate Names	GM-CSF
背景信息	GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/macrophages and eosinophils. GM-CSF has also been reported to have a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.

产品信息
演示	The sterile filtered solution was lyophilized from 10mM Sodium Citrate, pH 3.5.

应用
应用	The Granulocyte Macrophage Colony Stimulating Factor protein (GM-CSF protein) is a potent species-specific stimulator of bone marrow cells.
主要应用	Cell Culture
应用说明	For most in vitro applications, human GM-CSF exerts its biological activity in the concentration range of 0.05 to 0.5 ng/mL. Responding cells are (partial list): Certain BM precursor cells. Optimal working dilutions must be determined by end user.

生物信息
纯度	Greater than 98% by SDS-PAGE analysis.
来源	E.coli
品种	Human
特异活性	Human GM-CSF is fully biologically active when compared to standards. The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 0.1 ng/mL, corresponding to a specific activity of >=1 x 10<sup>7</sup> units/mg.
Entrez基因编号	NM_000588.3
Entrez基因汇总	The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
基因符号	IL-3 IL3 MGC79399 MCGF MULTI-CSF MGC79398
UniProt编号	P08700
UniProt汇总	FUNCTION: SwissProt: P08700 # This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. SIZE: 152 amino acids; 17233 Da SUBUNIT: Monomer. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer cells. SIMILARITY: SwissProt: P08700 ## Belongs to the IL-3 family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	The lyophilized powder, though stable at room temperature, is best stored at -20ºC. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 2-8ºC for 1 week or -20ºC for future use. After reconstitution maintain at -20ºC in undiluted aliquots for up to six months.

包装信息
数量	20 µg

merck millipore,默克密理博,GF004,Granulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant human

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