- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M, Mk WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-692 品牌系列 Upstate
商名 - Upstate
描述 Anti-Sar1 Antibody 产品信息 格式 Purified 应用 应用 Detect Sar1 using this Anti-Sar1 Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 46-62 (CKDDRLGQHVPTLHPTSE) of human Sar1 (a and b isoforms), with an N-terminal cysteine added for conjugation purposes 宿主 Rabbit 特异性 Sar1 同种型 IgG 品种反应性 RatHumanMouseMonkey 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_020150.3
基因符号 - OTTHUMP00000060603
- SARA1
- masra2
- SAR1
- SARA
- Sara
纯化方法 Protein A purfied UniProt编号 - Q9Y6B6
- Q9NR31
UniProt汇总 FUNCTION: SwissProt: Q9Y6B6 # Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.
SIZE: 198 amino acids; 22410 Da
SUBUNIT: Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Golgi apparatus, Golgi stack membrane; Peripheral membrane protein (By similarity). Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region (By similarity).
TISSUE SPECIFICITY: Expressed in many tissues including small intestine, liver, muscle and brain.
DISEASE: SwissProt: Q9Y6B6 # Defects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]. CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The conditions are characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. & Defects in SAR1B are the cause of Anderson disease (ANDD) [MIM:607689]. Andersen disease is a lipid absorption disorder, quite similar to chylomicron retention disease (CMRD) and differs in the partitioning of lipid between membrane and cytoplasmic compartments. & Defects in SAR1B are the cause of chylomicron retention disease associated with Marinesco-Sjoegren syndrome (CMRD-MSS) [MIM:607692].
SIMILARITY: SwissProt: Q9Y6B6 ## Belongs to the small GTPase superfamily. SAR1 family.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from 3T3/A31 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 stable 2 years at -20°C from date of shipment 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,GF004,Granulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant human
下一件merck millipore产品：merck millipore,默克密理博,MAB3071,Anti-G Protein Goα Antibody, clone 1C
相关产品
merck millipore,默克密理博,MAB1976Z,Anti-Integrin αVβ3 Antibody, clone LM609, Azide Free
merck millipore,默克密理博,07-472,Anti-PTPα Antibody
merck millipore,默克密理博,341501,FeTMPyP - Calbiochem
merck millipore,默克密理博,AB10223,Anti-Scirr1 Antibody
merck millipore,默克密理博,MAB3071,Anti-G Protein Goα Antibody, clone 1C
merck millipore,默克密理博,04-1132,Anti-Rsk4 (NT) Antibody, clone EP1982Y, rabbit monoclonal
merck millipore,默克密理博,CBL1508,Anti-H-CAM Antibody, clone OX-50
merck millipore,默克密理博,FCIM025125,FlowCellect™ Mouse Th17 Intracellular Cytokine Kit
merck millipore,默克密理博,681679,Iron Chelator IV, 21H7 - Calbiochem