merck millipore,默克密理愽
  • merck millipore,默克密理博,681679,Iron Chelator IV, 21H7 - Calbiochem

  • merck millipore,默克密理博,681679,Iron Chelator IV, 21H7 - Calbiochem

    产品名称：Iron Chelator IV, 21H7 - Calbiochem
    产品型号：681679
    The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,681679,Iron Chelator IV, 21H7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681679,Iron Chelator IV, 21H7 - Calbiochem

    重要规格表

    经验配方
    C₁₈H₁₄BrN₃O₂
    描述
    概述 A cell-permeable salicylaldehyde-acylhydrazone iron chelator that is 20-times more efficient than DFO/desferrioxamine (Cat. No. 252750) in depleting intracellular iron in colon cancer SW480 cells. Iron chelators exert their biological activities by affecting iron-regulated enzymes and singaling events, including HIF1α transcription activation due to inhibition of PHD- (prolyl hydroxylase) mediated HIF1α degradation, as well as altered mRNA translations due to enhanced IRP (Iron Regulatory Protein) IREs (Iron Response Elements) binding. Cellular iron depletion is also reported to inhibit the growths of colorectal adenocarcinoma cultures, DLD-1 (IC50 = 0.6 and 2.9 µM, respectively, by 21H7 and DFO) and SW480 (IC50 = 1.0 and 3.8 µM, respectively, by 21H7 and DFO), as a result of Wnt signaling pathway blockage (Effective conc. = 5 µM 21H7 or 100 µM DFO).
    产品目录编号 681679
    品牌系列 Calbiochem®
    同义词 6-Bromo-Nʹ-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide
    参考
    参考 Song, S., et al. 2011. Cancer Res. 71, 7628.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₈H₁₄BrN₃O₂
    化学配方 C₁₈H₁₄BrN₃O₂
    Molar Mass 384.2
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,681679,Iron Chelator IV, 21H7 - Calbiochem

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