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merck millipore,默克密理博,SF-977,CDKN1A; Human, Cyanine 5, RNA Detection Probe,SmartFlare
产品名称：CDKN1A; Human, Cyanine 5, RNA Detection Probe, SmartFlare
产品型号：SF-977
Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare CDKN1A, Human, Cyanine 5, you can detect CDKN1A RNA levels within your cells.
merck millipore,默克密理博,SF-977,CDKN1A; Human, Cyanine 5, RNA Detection Probe,SmartFlare
- 产品介绍
重要规格表
Entrez Gene Number Species Reactivity NM_078467.2 H 描述 产品目录编号 SF-977 商名 - SmartFlare
描述 CDKN1A; Human, Cyanine 5, RNA Detection Probe | SmartFlare Alternate Names - SDI1
- P21
- CIP1
背景信息 With SmartFlare™ RNA Detection probes, you can detect RNA in LIVE CELLS with ease. With just an overnight incubation of CDKN1A; Human, Cyanine 5, RNA Detection Probe you can detect the presence of CDKN1A within your cells.
The tumor suppressor p53 transcriptionally activates a number of genes including the WAF1/CIP1 gene in response to DNA damage. The ~21 kDa product of the WAF1 gene is found in a complex involving cyclins, cyclin dependent kinases (CDK), and PCNA in normal cells but not transformed cells and appears to be a universal inhibitor of CDK activity. One consequence of p21WAF1 binding to and inhibiting CDKs is to prevent CDK-dependent phosphorylation and subsequent inactivation of the Rb protein which is essential for cell cycle progression. p21WAF1 is, therefore, a potent and reversible inhibitor of cell cycle progression at both the G1 and G2 checkpoints, presumably to allow sufficient time for DNA repair to be completed. Irreversible G1 or G2 arrest leads to apoptosis. However, the role of p21WAF1 in apoptosis is less clear although p53-mediated apoptosis leads to increased WAF1 expression. Induction of p21WAF1 in response to DNA damage can occur by both p53-dependent and p53-independent mechanisms, in response to mitogenic stimuli, differentiation, or in tumor cells with mutated p53. Functional p21WAF1 is essential for p53-mediated G1 arrest presumably due to WAF1 inhibition of both CDK activity and PCNA-dependent DNA replication. WAF1 has also been identified as a gene involved in cellular senescence, termed sdi1. Not surprisingly, p21WAF1 overexpression is growth suppressive, consistent with its role as an inhibitor of CDKs. By inhibiting Rb inactivation in a p53-dependent fashion, p21WAF1 serves to integrate cell cycle control mediated by p53 and Rb.产品信息 格式 Cyanine 5 演示 Lyophilized 应用 应用 Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare CDKN1A, Human, Cyanine 5, you can detect CDKN1A RNA levels within your cells. 主要应用 - RNA Detection
生物信息 品种反应性 Human Entrez基因编号 - NM_078467.2
基因符号 - CDKN1A
产品使用声明 质量保证 SmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at 2–8°C in lyophilized format ONLY. Room temperature is required for reconstituted product. 包装信息 数量 250 reactions
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