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  • merck millipore,默克密理博,S7802,CpG WIZ p15 -Methylation specific PCR assay

  • merck millipore,默克密理博,S7802,CpG WIZ p15 -Methylation specific PCR assay

    产品名称：CpG WIZ p15 -Methylation specific PCR assay
    产品型号：S7802
    The CpG WIZ p15 Amplification Kit is used for determining the methylation status of the p15 promoter by methylation-specific PCR (MSP).

    merck millipore,默克密理博,S7802,CpG WIZ p15 -Methylation specific PCR assay

  • 产品介绍
  • merck millipore,默克密理博,S7802,CpG WIZ p15 -Methylation specific PCR assay

    描述
    产品目录编号 S7802
    品牌系列 Chemicon®
    商名
    • Chemicon
    • CpG Wiz
    描述 CpG WIZ® p15 -Methylation specific PCR assay
    概述 Aberrant methylation of the p15 promoter region has been shown to cause inactivation in several gliomas and leukemias. The CpG WIZ® p15 Amplification Kit is used for determining the methylation status of the p15 promoter by methylation-specific PCR (MSP). The kit contains primers targeted to regions of the p15 promoter where the sequences are most divergent after bisulfite treatment. PCR parameters have been identified so that all primer sets in the kit amplify template under the same conditions. Control genomic DNA samples (methylated and unmethylated) for p15* are also included.



    Methylation-specific PCR (MSP) is a new technology for sensitive detection of abnormal gene methylation utilizing small amounts of DNA (Herman, 1996 ). This process employs an initial bisulfite reaction to modify the DNA, followed by PCR amplification with specific primers designed to distinguish methylated from unmethylated DNA.



    *p15 is covered under U.S. patents 5,994,095, US 6,140,473, 6,180,776, 6,210,949 and 6,218,146.
    应用
    应用 The CpG WIZ p15 Amplification Kit is used for determining the methylation status of the p15 promoter by methylation-specific PCR (MSP).
    主要应用
    • PCR
    应用说明 Principles of the Technique

    Use of either the CpGenome™ DNA Modification Kit (Cat. No. S7820) or the CpGENOME™ Fast DNA Modification Kit (Cat. No. S7824) facilitates the initial bisulfite reactions, while the The CpG WIZ® p15 Amplification Kit contains the reagents required for the gene-specific PCR amplification reactions.
    生物信息
    品种反应性 Human
    Entrez基因编号
    • NM_078487.2
    • NM_004936.3
    Entrez基因汇总 This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
    基因符号
    • p15_INK4B
    • CDKN2B
    • TP15
    • INK4B
    • p15INK4b
    • p14-INK4b
    • P15
    • MTS2
    • p15-INK4b
    • MTS-2
    • p14_INK4B
    • p15INK4B
    • CDK4I
    UniProt编号
    • P42772
    UniProt汇总 FUNCTION: SwissProt: P42772 # Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
    SIZE: 138 amino acids; 14722 Da
    SUBUNIT: Heterodimer of CDKN2B with CDK4 or CDK6.
    DISEASE:SwissProt: P42772 # Defects in CDKN2B are involved in tumor formation.
    SIMILARITY: SwissProt: P42772 ## Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. & Contains 4 ANK repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 25 assays

    merck millipore,默克密理博,S7802,CpG WIZ p15 -Methylation specific PCR assay

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