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品种反应性 主要应用 宿主 格式 抗体类型 H FC M Purified Monoclonal Antibody 描述 产品目录编号 MABT70 描述 Anti-CD62L Antibody, clone LAMI-116 Alternate Names - LECAM1
- qp90-MEL
- TQ1
- CD62L
- LAM1
- LEU8
- LSEL
- PLNHR
背景信息 L-selectin (CD62L) expression improves immune surveillance by encoding CD4+ T cell blood and lymph node spreading. Increased expression of CD62L has been linked to increased stress and certain panic disorders. It has been shown that CD4+ cells expressing CD62L can prevent the onset of diabetes. Subjects with cryptococcosis have been shown to have more soluble CD62L in the serum. The inability to get rid of CD62L may enhance leukocyte-mediated end-organ injury in patients with sepsis. 产品信息 格式 Purified 控制 - Human PBMCs
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-CD62L Antibody, clone LAMI-116 detects level of CD62L & has been published & validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Recombinant protein corresponding to human CD62L. 克隆 LAMI-116 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000646
Entrez基因汇总 This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. 基因符号 - LYAM1
- SELL
- LNHR
纯化方法 Protein G Purified UniProt编号 - P14151
UniProt汇总 FUNCTION: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
SUBUNIT STRUCTURE: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on Y-51 of PSGL1 is important for L-selectin binding.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.产品使用声明 质量保证 Evaluated by Flow Cytometry in human PBMCs.
Flow Cytometry Analysis: 0.5 µg of this antibody detected CD62L in human PBMCs.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,HTS114M,ChemiSCREEN™ Human PAC1-long Receptor Membrane Preparation
下一件merck millipore产品：merck millipore,默克密理博,MAB515P-K,Digoxin, Ms Anti (1mg)
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