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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB5852 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-SHANK1a Antibody, NT 背景信息 Shank is a novel family of postsynaptic density proteins (PSD) that bind to PDS-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1. 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. 应用 应用 Anti-SHANK1a Antibody, N-terminus is an antibody against SHANK1a for use in WB. 主要应用 - Western Blotting
应用说明 Western blotting: 1:500-1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to the N-terminus of rat Shank1a. 表位 N-terminus 宿主 Rabbit 特异性 Recognizes Shank1a, N-terminal. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_016148.2
基因符号 - synamon
- SHANK1
- SSTRIP
- SPANK-1
- Shank1
UniProt编号 - Q9Y566
UniProt汇总 FUNCTION: SwissProt: Q9Y566 # Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
SIZE: 2161 amino acids; 225021 Da
SUBUNIT: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD- 95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity).TISSUE SPECIFICITY: Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
SIMILARITY: SwissProt: Q9Y566 ## Belongs to the SHANK family. & Contains 6 ANK repeats. & Contains 1 PDZ (DHR) domain. & Contains 1 SAM (sterile alpha motif) domain. & Contains 1 SH3 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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