merck millipore,默克密理愽
  • merck millipore,默克密理博,324387,Dopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem

  • merck millipore,默克密理博,324387,Dopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem

    产品名称：Dopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem
    产品型号：324387
    The Dopamine Receptor Antagonist II, Thioridazine, HCl, also referenced under CAS 130-61-0, controls the biological activity of Dopamine Receptor. This small molecule/inhibitor is primarily used for B More>>

    merck millipore,默克密理博,324387,Dopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324387,Dopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₂₆N₂S₂ •HCl130-61-0
    描述
    概述 A phenothiazine class antipsychotic and dopamine receptor (DR) antagonist that is reported to exhibit CSCs- (cancer stem cells) differentiating (EC50 ≤9.4 µM for v1H9) and anti-leukemic activity, without affecting non-neoplastic H9 hESC, adult fibroblast-derived iPSC, or HSPCs (hematopoietic stem-progenitor cells). However, Thioridazine's high effective concentration (10 µM) against cancer cells suggests that other unidentified cellular targets/mechanisms in addition to DR antagonism may be also involved in its overall anti-CSC impact. Effectively augments AraC (Cat. No. 251010) in inhibiting primary AML in vitro colony formation (by 79%, 55%, and 100%, respectively, with 10 µM Thioridazine, 0.1 µM AraC, or a combination of both).
    产品目录编号 324387
    品牌系列 Calbiochem®
    同义词 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)-10H-phenothiazine, HCl, 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine, HCl
    参考
    参考 Sachlos, E., et al. 2012. Cell 149, 1284.
    产品信息
    CAS号 130-61-0
    形式 Off-white solid
    Hill配方 C₂₁H₂₆N₂S₂ •HCl
    化学配方 C₂₁H₂₆N₂S₂ •HCl
    Molar Mass 407.0
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324387,Dopamine Receptor Antagonist II, Thioridazine, HCl - CAS 130-61-0 - Calbiochem

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