merck millipore,默克密理博,FCMAB386F,Milli-Mark™ Anti-GSK3-FITC Antibody, clone 4G-1E

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	M	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB386F
商名	Milli-Mark
描述	Milli-Mark™ Anti-GSK3-FITC Antibody, clone 4G-1E
Alternate Names	glycogen synthase kinase 3 alpha GSK-3 alpha
背景信息	Glycogen synthase kinase-3 (GSK-3), a multifunctional serine/threonine kinase, is a key regulator of numerous signaling pathways. Two isoforms of GSK-3 are reported in mammals: a 51 kDa GSK-3a and a 47 kDa GSK-3b. These two isoforms exhibit about 98% homology in their kinase domains, but share only about 36% identity in the last 76 C-terminal amino acid residues. GSK-3a contains a glycine-rich extension at its N-terminus. A minor (~15% of total) splice variant of GSK-3b, GSK-3b2, has also been identified, which contains a 13-residue insert within the kinase domain. It exhibits reduced kinase activity towards tau protein compared with ‘unspliced’ GSK-3b. GSK-3b2 is localized primarily to neuronal cell bodies, unlike unspliced GSK-3b that is also found in neuronal processes. GSK-3b plays a key inhibitory role in the Wnt signaling pathway. Wnt genes encode a large family of secreted, cysteine-rich proteins that are important in development and in maintenance of adult tissues. Abnormalities in Wnt signaling are reported to promote both human degenerative diseases and cancer.

产品信息
格式	FITC
控制	Jurkat cells
演示	Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	Milli-Mark Anti-GSK3-FITC Antibody, clone 4G-1E detects level of GSK3 & has been published & validated for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	Synthetic peptide derived from a region of the catalytic domain (between subdomain VII and VIII) of the Drosophila GSK3/shaggy enzyme, coupled to ovalbumin.
克隆	4G-1E
宿主	Mouse
特异性	Antibody recognizes GSK3.
同种型	IgG1
品种反应性	Human
Species Reactivity Note	Tested and passed on Human. Unconjugated antibody Cat. No. 05-412 is known to react with Mouse, Rat, Dictyostelium, and Vertebrates.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_063937
基因符号	DKFZp686D0638 GSK3A
纯化方法	Protein G Purified
UniProt编号	P49840
UniProt汇总	FUNCTION: SwissProt: P49840 # Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity). SIZE: 483 amino acids; 50981 Da SUBUNIT: Monomer (By similarity). SIMILARITY: SwissProt: P49840 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein

产品使用声明
质量保证	Evaluated by flow cytometry using Jurkat cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB386F,Milli-Mark™ Anti-GSK3-FITC Antibody, clone 4G-1E

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