merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB11012,Anti-CBX-4 Antibody, clone 10H10.2

  • merck millipore,默克密理博,MAB11012,Anti-CBX-4 Antibody, clone 10H10.2

    产品名称：Anti-CBX-4 Antibody, clone 10H10.2
    产品型号：MAB11012
    Use Anti-CBX-4 Antibody, clone 10H10.2 (Mouse Monoclonal Antibody) validated in WB, Mplex to detect CBX-4 also known as chromobox homolog 4.

    merck millipore,默克密理博,MAB11012,Anti-CBX-4 Antibody, clone 10H10.2

  • 产品介绍
  • merck millipore,默克密理博,MAB11012,Anti-CBX-4 Antibody, clone 10H10.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB11012
    描述 Anti-CBX-4 Antibody, clone 10H10.2
    Alternate Names
    • chromobox homolog 4
    背景信息 Chromeobox 4 (CBX4), also known as Pc2, is a polycomb group (PcG) protein that functions as a transcriptional suppressor. CBX4 is thought to act as a co-repressor of DNMT3B, inducing transcriptional repression independent of DNA methylation. CBX4 also acts as a SUMO E3 ligase, facilitating SUMO1 conjugation by UBE2I. CBX4 is phosphorylated on Thr495 by HIPK2 upon DNA damage, which enhances its E3 SUMO-protein ligase activity.
    产品信息
    格式 Purified
    控制
    • HeLa nuclear extract or NIH3T3 whole cell lysate
    演示 Purified mouse monoclonal IgG2bκ in PBS containing 0.05% sodium azide.
    应用
    应用 Use Anti-CBX-4 Antibody, clone 10H10.2 (Mouse Monoclonal Antibody) validated in WB, Mplex to detect CBX-4 also known as chromobox homolog 4.
    主要应用
    • Western Blotting
    应用说明 Luminex®:
    The antibody was shown to bind CBX4, but not CBX7 or CBX8, by Luminex® assay.
    生物信息
    免疫原品种 The immunogen was GST-tagged fusion protein containing amino acids 77-551 of murine CBX-4.
    克隆 10H10.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes CBX-4.
    同种型 IgG2bκ
    品种反应性 MouseHuman
    Species Reactivity Note Human and mouse. Does not react with rat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_007625
    基因符号
    • hPc2
    • PC2
    • NBP16
    • Pc2
    • hPC2
    非反应性品种
    • Rat
    纯化方法 Purified from ascites by protein G affinity chromatography.
    UniProt编号
    • O00257
    UniProt汇总 Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
    Pathway: Protein modification; protein sumoylation.
    Subunit structure: Interacts with histone H3-K9Me3 By similarity. Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with SUV39H1 and HIPK2.
    Subcellular location: Nucleus.
    Tissue specificity: Ubiquitous.
    Post-translational modification: Phosphorylated on Thr-495 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492.
    Sequence similarities: Contains 1 chromo domain.
    产品使用声明
    质量保证 Western Blot Analysis:
    1 μg/mL of this antibody detected CBX-4 on 20 ug of NIH3T3 cell lysate and HeLa nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB11012,Anti-CBX-4 Antibody, clone 10H10.2

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