merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT64,Anti-Nectin-4/PVRL4 Antibody, clone N4.61

  • merck millipore,默克密理博,MABT64,Anti-Nectin-4/PVRL4 Antibody, clone N4.61

    产品名称：Anti-Nectin-4/PVRL4 Antibody, clone N4.61
    产品型号：MABT64
    Anti-Nectin-4/PVRL4 Antibody, clone N4.61 is an antibody against Nectin-4/PVRL4 for use in IH, ELISA & IP.

    merck millipore,默克密理博,MABT64,Anti-Nectin-4/PVRL4 Antibody, clone N4.61

  • 产品介绍
  • merck millipore,默克密理博,MABT64,Anti-Nectin-4/PVRL4 Antibody, clone N4.61

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISA, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT64
    描述 Anti-Nectin-4/PVRL4 Antibody, clone N4.61
    Alternate Names
    • Nectin-4
    • poliovirus receptor-related 4
    • Ig superfamily receptor LNIR
    • nectin 4
    • poliovirus receptor-related protein 4
    • nectin-4
    背景信息 Nectin-4 is also known as poliovirus receptor-related protein 4 (PRR4 or PVRL4). Nectins are known for being the receptors for the herpes simplex virus. Nectin-4 is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. Nectin-4 is connected with the actin cytoskeleton through afadin inside the cell. Nectin-4 is predominantly found in human placenta although in mice, expression is wide-ranging. Nectin-4 seems to adhere primarily to cells expressing nectin-1 and vice versa.
    产品信息
    格式 Purified
    控制
    • Ductal carcinoma tissue
    演示 Purified mouse monoclonal IgG1κ Supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Nectin-4/PVRL4 Antibody, clone N4.61 is an antibody against Nectin-4/PVRL4 for use in IH, ELISA & IP.
    主要应用
    • ELISA
    • Immunohistochemistry
    应用说明 ELISA Anaysis: A previous lot was used by an independent laboratory in ELISA (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550).

    Immunoprecipitation Anaysis: A previous lot was used by an independent laboratory in IP (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550).
    生物信息
    免疫原品种 Recombinant protein corresponding to human Nectin-4.
    克隆 N4.61.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_112178
    Entrez基因汇总 Poliovirus receptor-like proteins (PVRLs), such as PVRL4, are adhesion receptors of the immunoglobulin superfamily and function in cell-cell adhesion (Reymond et al., 2001 [PubMed 11544254]).[supplied by OMIM].
    基因符号
    • LNIR
    • PVRL4
    • PRR4
    纯化方法 Protein G Purified
    UniProt编号
    • Q96NY8
    UniProt汇总 FUNCTION: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.

    SUBUNIT STRUCTURE: Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4.

    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein Potential. Cell junction › adherens junction. Note: Colocalizes with MLLT4 at cadherin-based adherens junctions.

    Processed poliovirus receptor-related protein 4: Secreted. Note: The secreted form is found in breast tumor patients.

    TISSUE SPECIFICTY: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

    PTM: The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.

    SEQUENCE SIMILARITIES: Belongs to the nectin family.

    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in ductal carcinoma tissue.

    Immunohistochemistry Analysis: A 1:400 dilution of this antibody detected Nectin-4/PVRL4 in ductal carcinoma tissue.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABT64,Anti-Nectin-4/PVRL4 Antibody, clone N4.61

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