merck millipore,默克密理愽
  • merck millipore,默克密理博,344096,InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

  • merck millipore,默克密理博,344096,InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

    产品名称：InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem
    产品型号：344096
    A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent.

    merck millipore,默克密理博,344096,InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,344096,InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₂₅FNNaO₄93957-55-2
    描述
    概述 A synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.
    产品目录编号 344096
    品牌系列 Calbiochem®
    同义词 (±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium
    参考
    参考 Yamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
    Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
    Ikeda, U., et al. 2000. Hypertension 36, 325.
    Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
    Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
    Yuan, J., et al. 1991. Atherosclerosis 87, 147.
    产品信息
    CAS号 93957-55-2
    形式 Liquid
    配方 A 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.
    Hill配方 C₂₄H₂₅FNNaO₄
    化学配方 C₂₄H₂₅FNNaO₄
    Molar Mass 433.5
    可逆 Y
    结构配方图像
    生物信息
    主靶 HMG-CoA reductase
    纯度 ≥98% by HPLC
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Standard Handling
    储存 ≤ -70°C
    避光 Protect from light
    避免冻结 / 解冻 Avoid freeze/thaw
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,344096,InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

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