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merck millipore,默克密理博,581810,(-)-Terreic Acid, Synthetic - CAS 121-40-4 - Calbiochem
产品名称：(-)-Terreic Acid, Synthetic - CAS 121-40-4 - Calbiochem
产品型号：581810
A cell-permeable quinone epoxide antibiotic that acts as a reversible, substrate competitive, and selective inhibitor of Bruton's tyrosine kinase catalytic activity (BTK; IC₅₀ = 10 µM and 3 µM for the More>>
merck millipore,默克密理博,581810,(-)-Terreic Acid, Synthetic - CAS 121-40-4 - Calbiochem
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重要规格表
经验配方 CAS号 C₇H₆O₄ 121-40-4 描述 概述 A cell-permeable quinone epoxide antibiotic that acts as a reversible, substrate competitive, and selective inhibitor of Bruton’s tyrosine kinase catalytic activity (BTK; IC50 = 10 µM and 3 µM for the basal and activation levels). Shown to bind to the BTK pleckstrin homology domain (BTK-PH) and block the interaction between the BTK-PH and PKC (IC50 = ~ 100 µM in human mast cell lysates), thus affecting the catalytic activity of BTK, but not of PKC. Selectively inhibits the autophosphorylating activity of PKCβI (IC50 = ~ 8 µM) and not of PKCβII. Reported to effectively inhibit the production of TNF-α (IC50 = ~ 3 µM), and activation of JNK1 (IC50 = ~ 10 µM) in FcεRI-stimulated mast cells. Also inhibits the DNA synthesis in activated spleen cells (IC50 = ~ 1.5 µM). Does not significantly affect the activities of Lyn, Syk, PKA, CK-1, ERK1, ERK2, and p38 kinases. 产品目录编号 581810 品牌系列 Calbiochem®
同义词 (1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione, BTK Inhibitor II, Bruton's Tyrosine Kinase Inhibitor II 参考 参考 Kawakami, Y., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 7423.
Kawakami, Y., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 2227.
Yamamoto, H., et al. 1980. Jpn. J. Antibiot. 33, 320.产品信息 CAS号 121-40-4 具有ATP竞争性 Y 形式 Light beige solid Hill配方 C₇H₆O₄ 化学配方 C₇H₆O₄ Molar Mass 154.2 可逆 Y 结构配方图像 生物信息 主靶 Bruton's tyrosine kinase catalytic activity (BTK) 主靶IC50 10 µM against BTK 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 H₂O GHS安全信息 RTECS RN8925000 储存和货运信息 货运代码 Blue Ice Only
毒性 Harmful
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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