- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,373270,Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem
产品名称：Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem
产品型号：373270
The Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1, also referenced under CAS 313553-47-8, controls the biological activity of Hec1/Nek2 Mitotic Pathway.
merck millipore,默克密理博,373270,Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,373270,Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem
重要规格表
经验配方 CAS号 C₁₈H₁₆N₂OS 313553-47-8 描述 概述 A cell-permeable thiazolyl benzamide compound that directly binds Hec1 and disrupts Hec1/Nek2 complex formation, resulting in defective Hec1 kinetochores localization and cellular Nek2 destabilization/downregulation. Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI50 of 10-21 µM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI50 = 41 µM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo. 产品目录编号 373270 品牌系列 Calbiochem®
同义词 N-(4-(2,4-Dimethylphenyl)-thiazol-2-yl)-benzamide, INH1, Inhibitor of Nek2/Hec1-1 参考 参考 Wu, G., et al. 2008. Cancer Res. 68, 8393. 产品信息 CAS号 313553-47-8 形式 White solid Hill配方 C₁₈H₁₆N₂OS 化学配方 C₁₈H₁₆N₂OS Molar Mass 308.4 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,MAB10420,Anti-Plexin B2 Antibody, clone 1D5.2
下一件merck millipore产品：merck millipore,默克密理博,513022,PD 150606 - CAS 426821-41-2 - Calbiochem
相关产品
merck millipore,默克密理博,04-1059,Anti-phospho-STAT3 (Tyr705) Antibody, clone EP2147Y, rabbit monoclonal
merck millipore,默克密理博,391338,HEPES, Free Acid, ULTROL Grade - CAS 7365-45-9 - Calbiochem
merck millipore,默克密理博,AB142,Anti-Galactocerebroside Antibody
merck millipore,默克密理博,MAB10420,Anti-Plexin B2 Antibody, clone 1D5.2
merck millipore,默克密理博,513022,PD 150606 - CAS 426821-41-2 - Calbiochem
merck millipore,默克密理博,581810,(-)-Terreic Acid, Synthetic - CAS 121-40-4 - Calbiochem
merck millipore,默克密理博,20-304,50mM AMP
merck millipore,默克密理博,233264,CMP-Sialic Acid, Disodium Salt - CAS 3063-71-6 - Calbiochem
merck millipore,默克密理博,AB15556-200UL,Anti-Somatostatin Receptor Type 5 Antibody