merck millipore,默克密理愽
  • merck millipore,默克密理博,528825,PARP Inhibitor XV, UPF-1035 - CAS 370872-09-6 - Calbiochem

  • merck millipore,默克密理博,528825,PARP Inhibitor XV, UPF-1035 - CAS 370872-09-6 - Calbiochem

    产品名称：PARP Inhibitor XV, UPF-1035 - CAS 370872-09-6 - Calbiochem
    产品型号：528825
    The PARP Inhibitor XV, UPF-1035, also referenced under CAS 370872-09-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,528825,PARP Inhibitor XV, UPF-1035 - CAS 370872-09-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,528825,PARP Inhibitor XV, UPF-1035 - CAS 370872-09-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₁NO₃370872-09-6
    描述
    概述 A cell-permeable isoquinolinone compound that acts as an NAD+-binding site-targeting, PARP-2-selective inhibitor (IC50 against murine PARP-2 and bovine PARP-1 = 0.15 and 8.0 µM, respectively). Reported to preferentially inhibit PARP activity in nuclear extracts derived from PARP-1-/- over PARP-1+/+ murine fibroblasts (by 80% and 15%, respectively, at 10 µM), while exhibiting little effect against tankyrase-1-dependent mitotic spindle formation in HeLa cells even at concentrations as high as 100 µM.
    产品目录编号 528825
    品牌系列 Calbiochem®
    同义词 5-Benzoyloxyisoquinolin-1(2H)-one
    参考
    参考 Moroni, F., et al. 2009. Br. J. Pharmacol. 157, 854.
    Pellicciari, R., et al. 2008. ChemMedChem 3, 914.
    产品信息
    CAS号 370872-09-6
    形式 Pale beige solid
    Hill配方 C₁₆H₁₁NO₃
    化学配方 C₁₆H₁₁NO₃
    Molar Mass 265.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,528825,PARP Inhibitor XV, UPF-1035 - CAS 370872-09-6 - Calbiochem

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