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merck millipore,默克密理博,MABT63,Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4
产品名称：Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4
产品型号：MABT63
Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4 detects level of Nectin-3/PVRL3 (CD113) & has been published & validated for use in FC.
merck millipore,默克密理博,MABT63,Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M Purified Monoclonal Antibody 描述 产品目录编号 MABT63 描述 Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4 Alternate Names - CD113 antigen
- poliovirus receptor-related 3
- poliovirus receptor-related protein 3
- nectin 3
- nectin-3
- Nectin-3
背景信息 Nectin-3, also known as Poliovirus receptor-related protein 3 (PVRL3) and PRR3, is thought to work with cadherin to form cell-cell adherens junctions. It is a transmembrane protein that is commonly found in the testis and in placental tissue. Nectin-3 colocalizes with CD155, the cognate receptor for poliovirus, to cell-cell junctions. Nectin-3's involvement in down-regulation PVR from the cell surface leads to a reduction in cell motility and proliferation. 产品信息 格式 Purified 控制 - U251 cells
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4 detects level of Nectin-3/PVRL3 (CD113) & has been published & validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Full length recombinant protein corresponding to human Nectin-3. 克隆 N3.12.4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_056295
Entrez基因汇总 Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells. [supplied by OMIM]. 基因符号 - PVRR3
- CDw113
- PRR3
- PPR3
- CD113
纯化方法 Protein G Purified UniProt编号 - Q9NQS3
UniProt汇总 FUNCTION: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
SUBUNIT STRUCTURE: Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT.
SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein Potential.
TISSUE SPECIFICTY: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
SEQUENCE SIMILARITIES: Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SEQUENCE CAUTION: The sequence AAH17572.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Flow Cytometry in U251 cells.
Flow Cytometry Analysis: 0.1 µg of this antibody detected Nectin-3 in U251 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 50 µg
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