merck millipore,默克密理博,MAB4307,Anti-Mouse Leukemia Inhibitory Factor Antibody, clone 2H2.2

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	WB, ELISA	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB4307
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Mouse Leukemia Inhibitory Factor Antibody, clone 2H2.2
Alternate Names	mLIF
背景信息	Leukemia inhibitory factor, or LIF, is a pleiotropic cytokine that is expressed by a wide variety of cells including activated T lymphocytes, monocytes, mast cells and neuronal cells. Human LIF cDNA encodes a 202 amino acid precursor which is processed to yield a 180 amino acid, biologically active glycoprotein with an approximate molecular weight of 38-67 kDa. In addition to its involvement in the stimulation of acute-phase protein during inflammatory processes, LIF has also been implicated in promoting the survival and growth of axons in vitro. LIF signals through the LIF receptor, a heterodimer comprised of a 190 kDa LIFR subunit and the gp130 subunit common to the IL-6, IL-11, CNTF and OSM receptors. Janus tyrosine kinases, JAK1 and JAK2, are activated in response to LIF stimulation, which in turn phosphorylate Stat1 and Stat3 causing their nuclear translocation and the transcription of Stat-responsive genes.

产品信息
格式	Purified
控制	Mouse DA-1a cells
演示	Purified Immunoglobulin. Liquid in 0.02M PBS, 0.25M NaCl ph 7.6 with 0.1% Sodium Azide.

应用
应用	Anti-Mouse Leukemia Inhibitory Factor Antibody, clone 2H2.2 is an antibody against Mouse Leukemia Inhibitory Factor for use in ELISA & WB.
主要应用	Western Blotting ELISA
应用说明	Immunoblotting: a starting dilution of 1-10 μg/mL is suggested. EIA Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Recombinant Murine LIF.
克隆	2H2.2
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This antibody is reactive to E.coli and STO derived recombinant murine Leukemia Inhibitory Factor (LIF).
同种型	IgG1
品种反应性	Mouse
抗体类型	Monoclonal Antibody
Entrez基因汇总	Leukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes.
基因符号	CDF LIF HILDA MLPLI
UniProt编号	P09056 P15018
UniProt汇总	FUNCTION: SwissProt: P15018 # LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. SIZE: 202 amino acids; 22008 Da SUBCELLULAR LOCATION: Secreted. SIMILARITY: SwissProt: P15018 ## Belongs to the LIF/OSM family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MAB4307,Anti-Mouse Leukemia Inhibitory Factor Antibody, clone 2H2.2

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