merck millipore,默克密理愽
  • merck millipore,默克密理博,361546,GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem

  • merck millipore,默克密理博,361546,GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem

    产品名称：GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem
    产品型号：361546
    The GSK-3β Peptide Inhibitor, Cell-permeable controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,361546,GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,361546,GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem

    重要规格表

    经验配方
    C₆₆H₁₁₀N₁₅O₂₀P
    描述
    概述 A cell-permeable myristoylated form of GSK-3β Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3β (IC50 = 40 µM). Does not affect the activities of Cdc2, PKB, and PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~2.5-fold) in HEK293 cells and improve glucose tolerance in diabetic mice. Displays in vivo stability.
    产品目录编号 361546
    品牌系列 Calbiochem®
    同义词 L803-mts, Myr-N-GKEAPPAPPQSpP-NH₂
    参考
    参考 Plotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974.
    产品信息
    具有ATP竞争性 N
    声明 This product is covered by one or more US patents and/or patent applications and foreign counter-parts owned by Tel Aviv University Future Technology LP, a limited partnership formed under the laws of Israel. Purchase of this product conveys a non-exclusive license to use the product for research purposes only. Purchase of this product does not convey the right to (i) incorporate or use the product in the manufacture of any commercial product, (ii) sell or otherwise transfer the product to any third party, or (iii) use the product to provide any commercial service. THE PRODUCT IS NOT FOR USE IN HUMANS. For information on purchasing a license to this product for purposes other than research, contact VP Business Development, Ramot at Tel Aviv University Ltd., Tel Aviv University, Licensor-Aviv, Tel Aviv 61392, Israel, Phone: +972 3 640 6608; Fax: +972 3 640 6675.
    形式 Lyophilized white solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₆₆H₁₁₀N₁₅O₂₀P
    化学配方 C₆₆H₁₁₀N₁₅O₂₀P
    Molar Mass 1464.7
    吸湿 Hygroscopic
    肽序列 Myr-N-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-Ser(PO₃H)-Pro-NH₂
    可逆 N
    生物信息
    主靶 Gsk-3β
    主靶IC50 40 µM against Gsk-3β
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or CH₃CN:H₂O (1:1)
    肽序列 Myr-N-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-Ser(PO₃H)-Pro-NH₂
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,361546,GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem

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