merck millipore,默克密理博,324470,E-4031 - CAS 113558-89-7

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merck millipore,默克密理博,324470,E-4031 - CAS 113558-89-7 - Calbiochem
产品名称：E-4031 - CAS 113558-89-7 - Calbiochem
产品型号：324470
A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC₅₀ = 10 nM).

merck millipore,默克密理博,324470,E-4031 - CAS 113558-89-7 - Calbiochem

产品介绍

merck millipore,默克密理博,324470,E-4031 - CAS 113558-89-7 - Calbiochem

重要规格表

经验配方	CAS号
C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O	113558-89-7

描述
概述	A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K⁺ current (IK, IR) (IC₅₀ = 10 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity. A specific blocker of HERG channels (IC₅₀ = 7.7 nM).
产品目录编号	324470
品牌系列	Calbiochem®
同义词	4ʹ-[[1-[2-(6-Methyl-2-pyridinyl)ethyl-4-piperidinyl]carbonyl]methanesulfonanilide, 2HCl

参考
参考	Ficker, E., et al. 2000. Am. J. Physiol. 279, H1748. Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51. Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67. Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37. Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135. Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1. West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205. West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.

参考

Ficker, E., et al. 2000. Am. J. Physiol. 279, H1748.
Ono, K., et al. 2000. J. Physiol. (London) 524 (Pt. 1), 51.
Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol. 22, 67.
Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther. 2, 205.
West, P.D., et al. 1996. Pharmacol. Toxicol. 78, 89.

产品信息
CAS号	113558-89-7
具有ATP竞争性	N
形式	Solid
Hill配方	C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
化学配方	C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O
Molar Mass	510.5
吸湿	Hygroscopic
可逆	N
结构配方图像

生物信息
主靶	Inhibitor of the rapid type of inactivating inward-rectifying K+ current
主靶IC₅₀	10 nM inhibiting the rapid type of inactivating inward-rectifying K+ current
纯度	≥98% by TLC

理化信息
细胞可渗透	N
溶解度	H₂O

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.