merck millipore,默克密理博,196000,Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2

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merck millipore,默克密理博,196000,Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem
产品名称：Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem
产品型号：196000
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM).

merck millipore,默克密理博,196000,Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

产品介绍

merck millipore,默克密理博,196000,Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

重要规格表

经验配方	CAS号
C₃₅H₅₈O₉	88899-55-2

描述
概述	A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
概述	Note: 1 set = 3 x 10 µg
产品目录编号	196000
品牌系列	Calbiochem®

参考
参考	Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049. Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255. Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379. Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577. Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575. Drose, S., et al. 1993. Biochemistry 32, 3902. Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

参考

Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

产品信息
CAS号	88899-55-2
形式	White solid
Hill配方	C₃₅H₅₈O₉
化学配方	C₃₅H₅₈O₉
Molar Mass	622.8
结构配方图像

生物信息
主靶	vacuolar type H⁺ ATPase
主靶IC₅₀	500 pM
纯度	≥90% by HPLC

理化信息
溶解度	DMSO or EtOH

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 22-26-36 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.