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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-404 品牌系列 Upstate
商名 - Upstate
描述 Anti-PRMT1 Antibody 背景信息 The methylation of arginine is mediated by the Protein Arginine Methyl Transferase (PRMT) family of enzymes. These enzymes transfer the methyl group from S-adenosyl-Lmethionine to the guanidino nitrogen atoms of an arginine residue. Arginine methylation was found to be an important modification in signal transduction, transcription, RNA transport, and splicing. PRMT1, also known as HRMT1L2 and IR1B4, was isolated through its interaction with BTG1 and TIS21, proteins that are important in cell quiescence. PRMT1 is a 361 amino acid protein; its splicing variants differ at the N-terminus, giving rise to three isoforms of 343, 361, and 347 amino acids (variants 1, 2, and 3 respectively). Proteins involved in the metabolism of RNA are substrates for PRMT1, among them Sam68. 产品信息 格式 Purified 控制 - Jurkat cell lysate
演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-PRMT1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of PRMT1 & has been validated in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Peptide corresponding to residues 298-318 of human protein arginine methyltransferase 1. 宿主 Rabbit 特异性 PRMT1 doublet 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001536 and others
Entrez基因汇总 The PRMT1 gene encodes a protein arginine methyltransferase that functions as a histone methyltransferase specific for H4 (see MIM 602822).[supplied by OMIM] 基因符号 - HRMT1L2
- PRMT1
- IR1B4
- HCP1
- HMT2
- ANM1
纯化方法 Protein A purfied UniProt编号 - Q99873
UniProt汇总 FUNCTION: SwissProt: Q99873 # Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (may methylate HNRNPA1 and histones). Methylates SUPT5H.
SIZE: 361 amino acids; 41516 Da
SUBUNIT: Homodimer. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: SwissProt: Q99873 ## Belongs to the protein arginine N-methyltransferase family.产品使用声明 质量保证 routinely evaluated by immunoblot in lysates from Jurkat and 3T3/A31, NIH 3T3, HeLa, and mouse ES cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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下一件merck millipore产品：merck millipore,默克密理博,SF-908,MDM2; Human, Cyanine 5, RNA Detection Probe,SmartFlare
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